NANOCAPSULE COMPOSITIONS FOR THE CONTROLLED RELEASED OF AGENTS OF THERAPEUTIC INTEREST

WIPO Patent Application WO/2019/137948

A1

The present invention provides sustained release polymeric nanocapsules capable of releasing proteases such as collagenase with a controlled kinetic and a prolonged and sustainable effect over time(up to more than 10 days). Additionally, these nanocapsules protect the housed protease, preferably collagenase,against external aggressions maintaining its catalytic activity. In this way, this invention overcomes the currents problems associated with collagenase administration using a precise combination of monomers and cross-linkers, as described in the claims that allow the formation of degradable polymeric nanocapsules with collagenase embedded within. These capsules provide a sustained release of the housed enzyme thus providing a therapeutic improvement in comparison to current therapies thus decreasing the need for repeated injections or high collagenase doses.

VALLET REGÍ MARÍA (ES)
VILLEGAS DÍAZ MARÍA ROCÍO (ES)
BAEZA GARCÍA ALEJANDRO (ES)
ORTIZ ROMERO PABLO LUIS (ES)
PABLOS ÁLVAREZ JOSÉ LUIS (ES)
USATEGUI CORRAL ALICIA (ES)

PCT/EP2019/050425

July 18, 2019

January 09, 2019

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FUNDACION PARA LA INVESTIG BIOMEDICA DEL HOSPITAL 12 DE OCTUBRE (ES)
UNIV MADRID COMPLUTENSE (ES)

A61K9/51; B01J13/14; A61K38/48

WO2017205541A1	2017-11-30
WO2013033717A1	2013-03-07

MARÍA ROCÍO VILLEGAS ET AL: "Hybrid Collagenase Nanocapsules for Enhanced Nanocarrier Penetration in Tumoral Tissues", ACS APPLIED MATERIALS & INTERFACES, vol. 7, no. 43, 21 October 2015 (2015-10-21), US, pages 24075 - 24081, XP055515618, ISSN: 1944-8244, DOI: 10.1021/acsami.5b07116

FUSTER, Gustavo (ES)

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