NANOCAPSULES INTENDED FOR TRANSFERRING TOXIC DRUGS TO THE SITES OF INVASIVE DISEASES OCCURRENCE IN A PATIENT BODY AND METHOD OF THEIR PREPARATION

WIPO Patent Application WO/2010/134829

A3

Nanocapsules intended for a toxic drugs transfer to the sites of invasive diseases occurrence in patient body and method of their preparation Nanocapsules filled inside with aqueous solution of toxic drug, are hardened micelles of dimensions 20-250 nm and with coatings prepared from dextrans, compounds of silicon or chitosan, which are enclosed by the layer of cysteine peptidase inhibitor, with enzyme activity unit of purity ranging from 50 to 100 units in 1 mg of protein. Weight ratio of inhibitor to nanocapsules is ranged from 10 to 30 units counted over 1 g of nanocapsules bed. 10 Method for preparation of nanocapsules is based on the formation of micelles on the interface of chemical compounds with amphiphilic properties. Nanocapsules are obtained by solubilization of aqueous solution of therapeutic substance in a weak polar solvent, and coatings are formed by adding a substance into the outer phase, from which the coating is being formed, and by adding an oily substance, leading to the formation with coating substance a palisade accumulated on the water/oil interface. From obtained emulsion nanocapsules are precipitated, which are hardened and coupled by the immobilization method with cysteine peptidase inhibitor.

WO/2015/024931	PEPTIDIC NANODELIVERY COMPOSITION TARGETING TWO RECEPTORS
JP2013501224	Diagnosis and treatment targeting folic acid
WO/2002/070018	TETRADENTATE PEPTIDE-CHELATE CONJUGATES FOR COLORECTAL CANCER DIAGNOSIS

SIEWINSKI MACIEJ (PL)
MALOLEPSZA-JARMOLOWSKA KATARZYNA (PL)
BRYJAK MAREK (PL)
WITKIEWICZ WOJCIECH (PL)
MIKULEWICZ WOJCIECH (PL)
TRZISZKA TADEUSZ (PL)
KILAR EWA (PL)
SEBZDA TADEUSZ (PL)

PCT/PL2010/050017

August 11, 2011

May 21, 2010

Click for automatic bibliography generation  

AKADEMIA MEDYCZNA IM PIASTOW SLASKICH WE WROCLAWIU (PL)
SIEWINSKI MACIEJ (PL)
MALOLEPSZA-JARMOLOWSKA KATARZYNA (PL)
BRYJAK MAREK (PL)
WITKIEWICZ WOJCIECH (PL)
MIKULEWICZ WOJCIECH (PL)
TRZISZKA TADEUSZ (PL)
KILAR EWA (PL)
SEBZDA TADEUSZ (PL)

A61K47/48; A61K35/12; A61K35/22; A61K35/50; A61K35/54

PL190404B1

2005-12-30

MATEJA CEGNAR ET AL: "Cystatin incorporated in poly(lactide-co-glycolide) nanoparticles: development and fundamental studies on preservation of its activity", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 22, no. 5, 1 August 2004 (2004-08-01), pages 357 - 364, XP055000225, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2004.04.003
CEGNAR MATEJA ET AL: "Intracellular delivery of cysteine protease inhibitor cystatin by polymeric nanoparticles.", JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, vol. 6, no. 9-10, September 2006 (2006-09-01), pages 3087 - 3094, XP008137732, ISSN: 1533-4880, DOI: 10.1166/jnn.2006.401
NATASA OBERMAJER ET AL: "Immunonanoparticles - an effective tool to impair harmful proteolysis in invasive breast tumor cells", FEBS JOURNAL, vol. 274, no. 17, 1 September 2007 (2007-09-01), pages 4416 - 4427, XP055000234, ISSN: 1742-464X, DOI: 10.1111/j.1742-4658.2007.05971.x
CEGNAR M ET AL: "Poly(lactide-co-glycolide) nanoparticles as a carrier system for delivering cysteine protease inhibitor cystatin into tumor cells", EXPERIMENTAL CELL RESEARCH, vol. 301, no. 2, 10 December 2004 (2004-12-10), pages 223 - 231, XP004626708, ISSN: 0014-4827, DOI: DOI:10.1016/J.YEXCR.2004.07.021

WITEK, Rafał (Witek Sniezko & Partner, ul. Rudolfa Weigla 53-114 Wrocław, PL)

View/Download PDF      PDF Help

Previous Patent: THREE-DIMENSIONAL LOGICAL PUZZLE AND THE METHOD OF DETERMINING SHAPE OF ITS PIECES

Next Patent: TRITERPENOID DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS