Title:
NANOCARRIER FOR SELECTIVE FLUORESCENCE LABELING OF CANCER CELL AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/092984
Kind Code:
A1
Abstract:
An embodiment of the present invention provides a nanocarrier in a micelle structure, a pharmaceutical composition for diagnosis of cancer, comprising the same nanocarrier, and a method for preparing the same nanocarrier. The nanocarrier is obtained by dispersing a water-in-oil nanoemulsion containing an oil phase ingredient, a surfactant, and an aqueous phase ingredient inclusive of a cancer cell fluorescence-inducing substance and a cancer cell-targeting polysaccharide in water to remove the oil phase ingredient, whereby the nanocarrier includes the aqueous phase ingredient.
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Inventors:
LEE KANG WON (KR)
JEONG YOON (KR)
JEONG YOON (KR)
Application Number:
PCT/KR2017/001829
Publication Date:
May 24, 2018
Filing Date:
February 20, 2017
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
A61K49/00; A61K49/18; G01N33/574; G01N33/58
Foreign References:
| US9241921B2 | 2016-01-26 | |||
| KR19980014197A | 1998-05-25 |
Other References:
DE CAMPOS ARAÚJO LUCIANA MATTOSO PIRES, THOMAZINE JOSÉ ANTÔNIO, LOPEZ RENATA FONSECA VIANNA: "Development of microemulsions to topically deliver 5-aminolevulinic acid in photodynamic therapy.", EUR J PHARM BIOPHARM., vol. 75, no. 1, 18 January 2010 (2010-01-18), pages 48 - 55, XP027000720, DOI: 10.1016/j.ejpb.2010.01.008
PORRAS, M. ET AL.: "Properties of water-in-oil (W/O) nano-emulsions prepared by a low-energy emulsification method", COLLOIDS AND SURFACES A: PHYSICOCHEMICAL AND ENGINEERING ASPECTS, vol. 324, no. 1-3, 1 July 2008 (2008-07-01), pages 181 - 188, XP022735408, DOI: 10.1016/j.colsurfa.2008.04.012
WANG, JIANTING ET AL.: "Folate mediated self-assembled phytosterol-alginate nanoparticles for targeted intracellular anticancer drug delivery", COLLOIDS AND SURFACES B: BIOINTERFACES, vol. 129, 1 May 2015 (2015-05-01), pages 63 - 70, XP029158149, DOI: 10.1016/j.colsurfb.2015.03.028
YANG, S.J. ET AL.: "Alginate-folic acid-modified chitosan nanoparticles for photodynamic detection of intestinal neoplasms.", BIOMATERIALS., vol. 32, no. 8, March 2011 (2011-03-01), pages 2174 - 2182, XP055599586, DOI: 10.1016/j.biomaterials.2010.11.039
JEONG, Y. ET AL: "Selective uptake by cancer cells based on 5-aminolevulinic acid (5-ALA) for fluorescence image guided surgery", 20TH ANNIVERSARY INTERNATIONAL SYMPOSIUM OF THE KSBM, SOC-12, 29 September 2016 (2016-09-29)
LEE,K. ET AL: "Biomedical imaging applications of fluorescence-based nanotechnology", 2016 ANNUAL FALL MEETING OF THE KOREAN BIOCHIP SOCIETY (GUEST LECTURE), SVI-4, 28 October 2016 (2016-10-28), XP009518003
MA ET AL.: "Targeted Delivery of 5 Aminolevulinic Acid by Multifunctional Hollow Mesoporous Silica Nanoparticles for Photodynamic Skin Cancer Therapy", ACS APPL. MATER. INTERFACES, vol. 7, 2015, pages 10671 - 10676
JIN ET AL.: "Intracellular Dual Fluorescent Lightup Bioprobes for Image-Guided Photodynamic Cancer Therapy", SMALL, vol. 12, no. 28, 2016, pages 3870 - 3878
See also references of EP 3542826A4
PORRAS, M. ET AL.: "Properties of water-in-oil (W/O) nano-emulsions prepared by a low-energy emulsification method", COLLOIDS AND SURFACES A: PHYSICOCHEMICAL AND ENGINEERING ASPECTS, vol. 324, no. 1-3, 1 July 2008 (2008-07-01), pages 181 - 188, XP022735408, DOI: 10.1016/j.colsurfa.2008.04.012
WANG, JIANTING ET AL.: "Folate mediated self-assembled phytosterol-alginate nanoparticles for targeted intracellular anticancer drug delivery", COLLOIDS AND SURFACES B: BIOINTERFACES, vol. 129, 1 May 2015 (2015-05-01), pages 63 - 70, XP029158149, DOI: 10.1016/j.colsurfb.2015.03.028
YANG, S.J. ET AL.: "Alginate-folic acid-modified chitosan nanoparticles for photodynamic detection of intestinal neoplasms.", BIOMATERIALS., vol. 32, no. 8, March 2011 (2011-03-01), pages 2174 - 2182, XP055599586, DOI: 10.1016/j.biomaterials.2010.11.039
JEONG, Y. ET AL: "Selective uptake by cancer cells based on 5-aminolevulinic acid (5-ALA) for fluorescence image guided surgery", 20TH ANNIVERSARY INTERNATIONAL SYMPOSIUM OF THE KSBM, SOC-12, 29 September 2016 (2016-09-29)
LEE,K. ET AL: "Biomedical imaging applications of fluorescence-based nanotechnology", 2016 ANNUAL FALL MEETING OF THE KOREAN BIOCHIP SOCIETY (GUEST LECTURE), SVI-4, 28 October 2016 (2016-10-28), XP009518003
MA ET AL.: "Targeted Delivery of 5 Aminolevulinic Acid by Multifunctional Hollow Mesoporous Silica Nanoparticles for Photodynamic Skin Cancer Therapy", ACS APPL. MATER. INTERFACES, vol. 7, 2015, pages 10671 - 10676
JIN ET AL.: "Intracellular Dual Fluorescent Lightup Bioprobes for Image-Guided Photodynamic Cancer Therapy", SMALL, vol. 12, no. 28, 2016, pages 3870 - 3878
See also references of EP 3542826A4
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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