Title:
NANOLIPOSOME CARRIER COMPOSITION HAVING KRAS AND P53 GENE EDITING FUNCTION
Document Type and Number:
WIPO Patent Application WO/2022/191431
Kind Code:
A1
Abstract:
The present invention relates to: a nanoliposome carrier composition in which are enclosed a hybrid of a guide RNA targeting a Cas9 protein and a KRAS gene, and a hybrid of a guide RNA targeting an ABE protein and a P53 gene; and an agent for treating anticancer drug-resistant pancreatic cancer, wherein the agent contains the nanoliposome carrier composition. Pancreatic cancer develops one or more genetic mutations and thereby develops resistance to gemcitabine, which is currently used as a therapeutic agent for pancreatic cancer. As a result, pancreatic cancer has a high mortality rate compared to other types of cancer. The nanoliposome of the present invention can fundamentally treat pancreatic cancer cells by removing the KRAS mutation while simultaneously editing the P53 mutation to generate a normal gene, and thus can be used as a highly effective anticancer drug.
Inventors:
YU KYEONG NAM (KR)
WON EUN JEONG (KR)
SHIM HEE JIN (KR)
WON EUN JEONG (KR)
SHIM HEE JIN (KR)
Application Number:
PCT/KR2022/001418
Publication Date:
September 15, 2022
Filing Date:
January 27, 2022
Export Citation:
Assignee:
MOOGENE MEDI CO LTD (KR)
International Classes:
A61K48/00; A61K9/127; A61K31/7068; A61K31/7088; A61K47/69; A61P35/00
Foreign References:
| KR101796036B1 | 2017-11-10 | |||
| KR101710026B1 | 2017-02-27 | |||
| KR102328197B1 | 2021-11-17 |
Other References:
MIRGAYAZOVA REGINA, KHADIULLINA RANIYA, CHASOV VITALY, MINGALEEVA RIMMA, MIFTAKHOVA REGINA, RIZVANOV ALBERT, BULATOV EMIL: "Therapeutic Editing of the TP53 Gene: Is CRISPR/Cas9 an Option?", GENES, vol. 11, no. 6, 1 January 2020 (2020-01-01), pages 704, XP055966562, DOI: 10.3390/genes11060704
DONATO COSCO, FEDERICO, MORITTU, BRITTI, TRAPASSO: "Gemcitabine-loaded liposomes: rationale, potentialities and future perspectives", INTERNATIONAL JOURNAL OF NANOMEDICINE, pages 5423, XP055344141, DOI: 10.2147/IJN.S34025
DONATO COSCO, FEDERICO, MORITTU, BRITTI, TRAPASSO: "Gemcitabine-loaded liposomes: rationale, potentialities and future perspectives", INTERNATIONAL JOURNAL OF NANOMEDICINE, pages 5423, XP055344141, DOI: 10.2147/IJN.S34025
Attorney, Agent or Firm:
OAM PATENT & TRADEMARK LAW FIRM (KR)
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