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Title:
NANOLIPOSOME-MICROBUBBLE CONJUGATE HAVING CAS9 PROTEIN, GUIDE RNA FOR INHIBITING EXPRESSION OF SRD5A2 GENE AND CATIONIC POLYMER COMPLEX ENCAPSULATED THEREIN, AND HAIR LOSS RELIEVING OR TREATING COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2019/078611
Kind Code:
A1
Abstract:
The present invention relates to a nanoliposome-microbubble conjugate having a Cas9 protein, a guide RNA for inhibiting the expression of an SRD5A2 gene and a cationic polymer complex encapsulated therein, and a hair loss relieving or treating composition containing same. A drug which is currently used as a hair loss therapeutic agent has disadvantages of severe side effects such as hyposexuality and erectile dysfunction and recurrence of hair loss in case of cessation of the drug treatment. However, by means of using the nanoliposome-microbubble conjugate of the present invention, SRD5A2, which induces hair loss, can substantially be inhibited and male pattern hair loss can effectively be treated.

Inventors:
RYU JEE-YEON (KR)
WON EUN-JEONG (KR)
LEE HAN A REUM (KR)
YU KYEONG-NAM (KR)
Application Number:
KR2018/012251
Publication Date:
April 25, 2019
Filing Date:
October 17, 2018
Export Citation:
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Assignee:
MOOGENE MEDI CO LTD (KR)
International Classes:
A61K47/69; A61K9/00; A61K48/00
Foreign References:
KR101710026B12017-02-27
KR20140018150A2014-02-12
KR20160074883A2016-06-29
KR101870694B12018-06-25
Other References:
PARK, S.: "Bee Venom Promotes Hair Growth in Association with Inhibiting 5 a-Reductase Expression", BIOL. PHARM. BULL., vol. 39, 2 April 2016 (2016-04-02), pages 1060 - 1068, XP055595205
Attorney, Agent or Firm:
OAM PATENT & TRADEMARK LAW FIRM (KR)
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