Title:
NANOMACHINERY FOR PREVENTION OR TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2023/033519
Kind Code:
A1
Abstract:
An aspect provides gold (Au) nanoparticles associated with the compound of chemical formula 1 or a salt thereof. The gold nanoparticles can act as nanomachinery to induce apoptosis and, particularly when provided together with 4-(hexylamino)-2,3-dimethyl-4-oxobut-2-enoic acid, can selectively kill cancer cells in an acidic condition. Accordingly, a pharmaceutical composition and a health functional food, each comprising the gold nanoparticles, can exhibit prophylactic, palliative, or therapeutic effects on cancer cells irrespective of cancer types.
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Inventors:
JEONG YOUNGDO (KR)
RYU JA-HYOUNG (KR)
CHOI HUYEON (KR)
KWAK SANG KYU (KR)
KIM CHAEKYU (KR)
RYU JA-HYOUNG (KR)
CHOI HUYEON (KR)
KWAK SANG KYU (KR)
KIM CHAEKYU (KR)
Application Number:
PCT/KR2022/012963
Publication Date:
March 09, 2023
Filing Date:
August 30, 2022
Export Citation:
Assignee:
ULSAN NAT INST SCIENCE & TECH UNIST (KR)
KOREA INST SCI & TECH (KR)
KOREA INST SCI & TECH (KR)
International Classes:
A61K9/14; A23L33/16; A61K33/242; A61K47/18; A61P35/00
Other References:
GENG YINGYING, AMANTE JOHN J., GOEL HIRA L., ZHANG XIANZHI, WALKER MELANIE R., LUTHER DAVID C., MERCURIO ARTHUR M., ROTELLO VINCEN: "Differentiation of Cancer Stem Cells through Nanoparticle Surface Engineering", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 14, no. 11, 24 November 2020 (2020-11-24), US , pages 15276 - 15285, XP093043160, ISSN: 1936-0851, DOI: 10.1021/acsnano.0c05589
SAHA KRISHNENDU, KIM SUNG TAE, YAN BO, MIRANDA OSCAR R., ALFONSO FELIX S., SHLOSMAN DENIS, ROTELLO VINCENT M.: "Surface Functionality of Nanoparticles Determines Cellular Uptake Mechanisms in Mammalian Cells", SMALL, WILEY, HOBOKEN, USA, vol. 9, no. 2, 28 January 2013 (2013-01-28), Hoboken, USA, pages 300 - 305, XP093043162, ISSN: 1613-6810, DOI: 10.1002/smll.201201129
KIM CHANG SOO, LE NGOC D. B., XING YUQING, YAN BO, TONGA GULEN YESILBAG, KIM CHAEKYU, VACHET RICHARD W., ROTELLO VINCENT M.: "The Role of Surface Functionality in Nanoparticle Exocytosis", ADVANCED HEALTHCARE MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 3, no. 8, 1 August 2014 (2014-08-01), DE , pages 1200 - 1202, XP093043165, ISSN: 2192-2640, DOI: 10.1002/adhm.201400001
KIM CHAEKYU, TONGA GULEN YESILBAG, YAN BO, KIM CHANG SOO, KIM SUNG TAE, PARK MYOUNG-HWAN, ZHU ZHENGJIANG, DUNCAN BRADLEY, CRERAN B: "Regulating exocytosis of nanoparticles via host–guest chemistry", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 13, no. 8, 28 February 2015 (2015-02-28), pages 2474 - 2479, XP093043166, ISSN: 1477-0520, DOI: 10.1039/C4OB02433H
BAJAJ AVINASH, MIRANDA OSCAR R., KIM IK-BUM, PHILLIPS RONNIE L., JERRY D. JOSEPH, BUNZ UWE H. F., ROTELLO VINCENT M.: "Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 106, no. 27, 7 July 2009 (2009-07-07), pages 10912 - 10916, XP093043167, ISSN: 0027-8424, DOI: 10.1073/pnas.0900975106
JEONG YOUNGDO, JIN SOYEONG, PALANIKUMAR L., CHOI HUYEON, SHIN EUNHYE, GO EUN MIN, KEUM CHANGJOON, BANG SEUNGHWAN, KIM DONGKAP, LEE: "Stimuli-Responsive Adaptive Nanotoxin to Directly Penetrate the Cellular Membrane by Molecular Folding and Unfolding", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 144, no. 12, 30 March 2022 (2022-03-30), pages 5503 - 5516, XP093043168, ISSN: 0002-7863, DOI: 10.1021/jacs.2c00084
SAHA KRISHNENDU, KIM SUNG TAE, YAN BO, MIRANDA OSCAR R., ALFONSO FELIX S., SHLOSMAN DENIS, ROTELLO VINCENT M.: "Surface Functionality of Nanoparticles Determines Cellular Uptake Mechanisms in Mammalian Cells", SMALL, WILEY, HOBOKEN, USA, vol. 9, no. 2, 28 January 2013 (2013-01-28), Hoboken, USA, pages 300 - 305, XP093043162, ISSN: 1613-6810, DOI: 10.1002/smll.201201129
KIM CHANG SOO, LE NGOC D. B., XING YUQING, YAN BO, TONGA GULEN YESILBAG, KIM CHAEKYU, VACHET RICHARD W., ROTELLO VINCENT M.: "The Role of Surface Functionality in Nanoparticle Exocytosis", ADVANCED HEALTHCARE MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 3, no. 8, 1 August 2014 (2014-08-01), DE , pages 1200 - 1202, XP093043165, ISSN: 2192-2640, DOI: 10.1002/adhm.201400001
KIM CHAEKYU, TONGA GULEN YESILBAG, YAN BO, KIM CHANG SOO, KIM SUNG TAE, PARK MYOUNG-HWAN, ZHU ZHENGJIANG, DUNCAN BRADLEY, CRERAN B: "Regulating exocytosis of nanoparticles via host–guest chemistry", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 13, no. 8, 28 February 2015 (2015-02-28), pages 2474 - 2479, XP093043166, ISSN: 1477-0520, DOI: 10.1039/C4OB02433H
BAJAJ AVINASH, MIRANDA OSCAR R., KIM IK-BUM, PHILLIPS RONNIE L., JERRY D. JOSEPH, BUNZ UWE H. F., ROTELLO VINCENT M.: "Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 106, no. 27, 7 July 2009 (2009-07-07), pages 10912 - 10916, XP093043167, ISSN: 0027-8424, DOI: 10.1073/pnas.0900975106
JEONG YOUNGDO, JIN SOYEONG, PALANIKUMAR L., CHOI HUYEON, SHIN EUNHYE, GO EUN MIN, KEUM CHANGJOON, BANG SEUNGHWAN, KIM DONGKAP, LEE: "Stimuli-Responsive Adaptive Nanotoxin to Directly Penetrate the Cellular Membrane by Molecular Folding and Unfolding", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 144, no. 12, 30 March 2022 (2022-03-30), pages 5503 - 5516, XP093043168, ISSN: 0002-7863, DOI: 10.1021/jacs.2c00084
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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