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Title:
NANOMETER HYDROXYAPATITE / NATURAL POLYMER COMPOSITE MATERIAL, PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/035573
Kind Code:
A1
Abstract:
A nanometer hydroxyapatite/natural polymer composite material, preparation method and use thereof are disclosed. The preparation method comprises adding natural polymer material into a mixed solution of ethanol, water and carbamide, adding sodium dihydrogen phosphate solution and calcium chloride solution to the solution resulted, conducting sealed-reaction. Wherein, the volume ratio of ethanol and water in the mixed solution is 2-6:1 and the concentration of carbamide in the mixed solution is 1-3g/100ml. The composite material obtained has thick mineralized layer, and can be used in the field of tissue engineering material in which high mechanical strength is required, such as bone tissue engineering material.

Inventors:
LI LIHUA (CN)
ZHOU CHANGREN (CN)
Application Number:
PCT/CN2010/071494
Publication Date:
March 31, 2011
Filing Date:
April 01, 2010
Export Citation:
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Assignee:
JI NAN UNIVERSITY (CN)
LI LIHUA (CN)
ZHOU CHANGREN (CN)
International Classes:
C08L5/08; A61L27/46; A61L27/56; C08K3/32; C08K9/04; C08L5/04; C08L89/00
Foreign References:
CN1389503A2003-01-08
CN101422632A2009-05-06
CN101559241A2009-10-21
US20090169524A12009-07-02
CN1775306A2006-05-24
Other References:
LU,XIAOYING ET AL.: "Preparation of Nano-Hydroxyapatite/Chitosan Hybrids", JOURNAL OF INORGANIC MATERIALS, vol. 23, no. 2, March 2008 (2008-03-01), pages 332 - 336
Attorney, Agent or Firm:
GUANGZHOU HUAXUE INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
广州市华学知识产权代理有限公司 (CN)
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