Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
NANOPARTICLE COMPRISING PEPTIDE-LIPID CONJUGATE FOR DELIVERING OLIGONUCLEOTIDE INTO TARGET CELL AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2022/260480
Kind Code:
A1
Abstract:
The present invention relates to a carrier for delivering oligonucleotides into cells for therapeutic use. To inhibit a target protein or promote expression of a target protein in a cell, a peptide-lipid conjugate is prepared, and a nanoparticle consisting of a peptide-lipid conjugate comprising oligonucleotides and a pharmaceutical composition comprising same are provided. It was confirmed that, by using the nanoparticle consisting of a peptide-lipid conjugate according to the present invention, oligonucleotides were effectively delivered into cells. In addition, by confirming that expression of a cancer-causing protein is reduced by the oligonucleotides and an anticancer effect is exhibited in an animal model in which cancer occurs, the nanoparticle consisting of a peptide-lipid conjugate was found to be effective in the delivery of oligonucleotides.

More Like This:
JP2021080186THERAPEUTIC AGENT FOR BILIARY TRACT CANCER OR PANCREATIC CANCER
JP2002281988SBSEMN1 POLYPEPTIDE AND POLYNUCLEOTIDE
WO/2012/159550FGFR-FC FUSION PROTEIN AND USE THEREOF
Inventors:
PARK YOON JEONG (KR)
CHUNG CHONG-PYOUNG (KR)
LEE JUE-YEON (KR)
Application Number:
PCT/KR2022/008229
Publication Date:
December 15, 2022
Filing Date:
June 10, 2022
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
NIBEC CO LTD (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
A61K48/00; A61K9/51; A61K31/7088; A61K31/713; A61K47/54; A61K47/64; A61K47/69; A61P29/00; A61P35/00
Domestic Patent References:
WO2019226940A12019-11-28
WO2009086558A12009-07-09
WO2009127060A12009-10-22
WO2009132131A12009-10-29
WO2010042877A12010-04-15
WO2010054384A12010-05-14
WO2010054401A12010-05-14
WO2010054405A12010-05-14
WO2010054406A12010-05-14
WO2010105209A12010-09-16
Foreign References:
KR20110043859A2011-04-28
US20060083780A12006-04-20
US20060240554A12006-10-26
US20080020058A12008-01-24
US20090263407A12009-10-22
US20090285881A12009-11-19
Other References:
KANG JI HEE, BATTOGTOKH GANTUMUR, KO YOUNG TAG: "Self-Assembling Lipid–Peptide Hybrid Nanoparticles of Phospholipid–Nonaarginine Conjugates for Enhanced Delivery of Nucleic Acid Therapeutics", BIOMACROMOLECULES, vol. 18, no. 11, 13 November 2017 (2017-11-13), US , pages 3733 - 3741, XP055794024, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b01084
LI HUA, TSUI TUNGYU: "Six-cell penetrating peptide-based fusion proteins for siRNA delivery", DRUG DELIVERY, vol. 22, no. 3, 3 April 2015 (2015-04-03), US , pages 436 - 443, XP093013496, ISSN: 1071-7544, DOI: 10.3109/10717544.2014.881439
IWASAKI TAKASHI; MURAKAMI NODOKA; KAWANO TSUYOSHI: "A polylysine–polyhistidine fusion peptide for lysosome-targeted protein delivery", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 533, no. 4, 30 September 2020 (2020-09-30), Amsterdam NL , pages 905 - 912, XP086405833, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2020.09.087
RYU YEONG CHAE, KIM KYUNG AH, KIM BYOUNG CHOUL, WANG HUI-MIN DAVID, HWANG BYEONG HEE: "Novel fusion peptide‐mediated siRNA delivery using self‐assembled nanocomplex", JOURNAL OF NANOBIOTECHNOLOGY, vol. 19, no. 44, 1 December 2021 (2021-12-01), pages 1 - 18, XP093013824, DOI: 10.1186/s12951-021-00791-x
"Remington's Pharmaceutical Science", MACK PUBLISHING COMPANY
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
Download PDF:
View/Download PDF      PDF Help



 
Previous Patent: COMPOSITION OF MIXED HERBAL MEDICINE EXTRACT FOR IMPROVING INTESTINAL MICROBIAL ENVIRONMENT

Next Patent: BOOT ASSEMBLY OF DRIVE AXLE