Title:
NANOPARTICLES FOR CHEMOTHERAPY FOR ANOIKIS-RESISTANT CANCER CELLS
Document Type and Number:
WIPO Patent Application WO/2017/200156
Kind Code:
A1
Abstract:
The present invention relates to albumin nanoparticles for chemotherapy for anoikis-resistant cancer cells, and more specifically, to albumin nanoparticles for chemotherapy for anoikis-resistant cancer cells, the albumin nanoparticles comprising: albumin nanoparticles having a drug impregnated therein; and a CEACAM6 antibody bonding with the albumin nanoparticles, wherein the albumin nanoparticles are formed by means of disulfide bonds formed among albumin molecules, and the CEACAM6 antibody forms an amide bond with an amine group on the surface of the albumin nanoparticles, and thus the CEACAM6 antibody targets anoikis-resistant cancer cells, and the albumin nanoparticles ingested by the cancer cells discharge the drug by having the disulfide bonds thereof broken due to glutathione existing in the cytosol.
Inventors:
KIM HYUN CHEOL (KR)
LEE HO HYUN (KR)
LEE HO HYUN (KR)
Application Number:
PCT/KR2016/011348
Publication Date:
November 23, 2017
Filing Date:
October 11, 2016
Export Citation:
Assignee:
UNIV SOGANG RES FOUNDATION (KR)
International Classes:
A61K31/704; A61K47/42
Foreign References:
| CN104490847A | 2015-04-08 |
Other References:
LEE, H. ET AL.: "Chemotherapy of Breast Cancer Cells during the Metastatic Phase by CEACAM6-Targeting Albumin Nanoparticles", ABSTRACTS OF KOREAN SOCIETY FOR BIOTECHNOLOGY AND BIOENGINEERING CONFERENCE, 2015, pages 523
SON, S. ET AL.: "Self-crosslinked Human Serum Albumin Nanocarriers for Systemic Delivery of Polymerized siRNA to Tumors", BIOMATERIALS, vol. 34, 2013, pages 9475 - 9485, XP055442534
LI, C. ET AL.: "Preparation and Characterization of Galactosylated Bovine Serumalbumin Nanoparticles for Liver-targeted Delivery of Oridonin", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 448, 2013, pages 79 - 86, XP028582060
WAGNER, S ET AL.: "Enhanced Drug Targeting by Attachment of an Anti av Integrin Antibody to Doxorubicin Loaded Human Serum Albumin Nanoparticles", BIOMATERIALS, vol. 31, 2010, pages 2388 - 2398, XP026870608
SON, S. ET AL.: "Self-crosslinked Human Serum Albumin Nanocarriers for Systemic Delivery of Polymerized siRNA to Tumors", BIOMATERIALS, vol. 34, 2013, pages 9475 - 9485, XP055442534
LI, C. ET AL.: "Preparation and Characterization of Galactosylated Bovine Serumalbumin Nanoparticles for Liver-targeted Delivery of Oridonin", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 448, 2013, pages 79 - 86, XP028582060
WAGNER, S ET AL.: "Enhanced Drug Targeting by Attachment of an Anti av Integrin Antibody to Doxorubicin Loaded Human Serum Albumin Nanoparticles", BIOMATERIALS, vol. 31, 2010, pages 2388 - 2398, XP026870608
Attorney, Agent or Firm:
KIM, Hyun Jin (KR)
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