Title:
NANOPARTICLES WITH BIODEGRADABLE AND BIOCOMPATIBLE POLYMER PLGA, LOADED WITH THE DRUG FOR HUMAN USE PENTOXIFYLLINE
Document Type and Number:
WIPO Patent Application WO/2014/075203
Kind Code:
A1
Abstract:
The invention relates to a novel pharmaceutical formulation comprising polymer nanoparticles of the biodegradable and biocompatible polymer poly (lactic-glycolic) acid (PLGA), loaded with the drug pentoxifylline, the method for the synthesis of the PLGA nanoparticles loaded with pentoxifylline, and to the use thereof in the effective treatment for the relief of chronic pain and for the prevention of chronic pain via the administration of a single dose.
Inventors:
CONSTANDIL CÓRDOVA LUIS ERNESTO (CL)
IBARRA DURÁN PAULA SOLEDAD (CL)
VILOS ORTÍZ CRISTIAN ANDRÉES (CL)
VELÁSQUEZ CUMPLIDO LUIS (CL)
PELISSIER SERRANO TERESA (CL)
LAURIDO FUENZALIDA CLAUDIO AURELIO (CL)
HERNÁNDEZ KUNSTMANN ALEJANDRO (CL)
IBARRA DURÁN PAULA SOLEDAD (CL)
VILOS ORTÍZ CRISTIAN ANDRÉES (CL)
VELÁSQUEZ CUMPLIDO LUIS (CL)
PELISSIER SERRANO TERESA (CL)
LAURIDO FUENZALIDA CLAUDIO AURELIO (CL)
HERNÁNDEZ KUNSTMANN ALEJANDRO (CL)
Application Number:
PCT/CL2013/000084
Publication Date:
May 22, 2014
Filing Date:
November 15, 2013
Export Citation:
Assignee:
UNIV SANTIAGO CHILE (CL)
International Classes:
A61K31/522; A61K47/34; A61P25/04; B82Y5/00
Domestic Patent References:
| WO2008054042A1 | 2008-05-08 | |||
| WO1995019174A1 | 1995-07-20 |
Foreign References:
| US20090263491A1 | 2009-10-22 |
Other References:
VARSHOSAZ JALEH ET AL.: "Enhancement of oral bioavailability of pentoxifylline by solid lipid nanoparticles.", JOURNAL OF LIPOSOME RESEARCH, vol. 20, no. 2, June 2010 (2010-06-01), pages 115 - 123, ISSN: 0898-2104
Attorney, Agent or Firm:
MOLINA VILLASECA, Eduardo (CL)
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