Title:
NANOSCALE PLATINUM COMPOUNDS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/091192
Kind Code:
A3
Abstract:
The invention is directed to biocompatible conjugated polymer nanoparticles including a copolymer backbone, a plurality of sidechains covalently linked to said backbone, and a plurality of platinum compounds dissociably linked to said backbone. The invention is also directed to dicarbonyl-lipid compounds wherein a platinum compound is dissociably linked to the dicarbonyl compound. The invention is also directed to methods of treating cancer or metastasis. The methods includes selecting a subject in need of treatment for cancer or metastasis and administering to the subject an effective amount of any of the nanoparticles, compounds, or compositions of the invention.
Inventors:
SENGUPTA SHILADITYA (US)
SONI SHIVANI (US)
PARASKAR ABHIMANYU (US)
SONI SHIVANI (US)
PARASKAR ABHIMANYU (US)
Application Number:
PCT/US2010/023217
Publication Date:
December 02, 2010
Filing Date:
February 04, 2010
Export Citation:
Assignee:
BRIGHAM & WOMENS HOSPITAL (US)
SENGUPTA SHILADITYA (US)
SONI SHIVANI (US)
PARASKAR ABHIMANYU (US)
SENGUPTA SHILADITYA (US)
SONI SHIVANI (US)
PARASKAR ABHIMANYU (US)
International Classes:
C08F222/06; A61K33/243; A61K47/48; A61P35/00; C08F8/42; C08F22/06
Foreign References:
| US20080145416A1 | 2008-06-19 | |||
| US20080063701A1 | 2008-03-13 | |||
| US20050136258A1 | 2005-06-23 |
Other References:
RAINER HAAG ET AL., POLYMER THERAPEUTICS : CONCEPT AND APPLICATIONS, 2006, pages 1198 - 1215, XP001240100
MOGANAVELLI SINGH ET AL.: "A cationic cytofectin with long spacer mediates favourable transfection", December 2005 (2005-12-01), pages 191, XP027972768
UTE SCHMIDT ET AL.: "Modification of Poly(octadecene-alt-maleic anhydride)films by Reaction with Functional Amines", vol. 87, 2003, pages 1255 - 1266, XP002427748
MOGANAVELLI SINGH ET AL.: "A cationic cytofectin with long spacer mediates favourable transfection", December 2005 (2005-12-01), pages 191, XP027972768
UTE SCHMIDT ET AL.: "Modification of Poly(octadecene-alt-maleic anhydride)films by Reaction with Functional Amines", vol. 87, 2003, pages 1255 - 1266, XP002427748
Attorney, Agent or Firm:
RESNICK, David, S. et al. (100 Summer StreetBoston, MA, US)
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