Title:
NANOSTRUCTURES SUITABLE FOR SEQUESTERING CHOLESTEROL
Document Type and Number:
WIPO Patent Application WO/2009/131704
Kind Code:
A3
Abstract:
Articles, compositions, kits, and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids. In some embodiments, the structures, when introduced into a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels.
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Inventors:
MIRKIN CHAD A (US)
THAXTON C SHAD (US)
GILJOHANN DAVID A (US)
DANIEL WESTON (US)
THAXTON C SHAD (US)
GILJOHANN DAVID A (US)
DANIEL WESTON (US)
Application Number:
PCT/US2009/002540
Publication Date:
September 10, 2010
Filing Date:
April 24, 2009
Export Citation:
Assignee:
UNIV NORTHWESTERN (US)
MIRKIN CHAD A (US)
THAXTON C SHAD (US)
GILJOHANN DAVID A (US)
DANIEL WESTON (US)
MIRKIN CHAD A (US)
THAXTON C SHAD (US)
GILJOHANN DAVID A (US)
DANIEL WESTON (US)
International Classes:
A61K9/00
Domestic Patent References:
| WO2007089607A2 | 2007-08-09 | |||
| WO1993021528A1 | 1993-10-28 | |||
| WO2008106660A2 | 2008-09-04 |
Foreign References:
| US20040053384A1 | 2004-03-18 |
Other References:
NIEMEYER C M ET AL: "Bifunctional DNA-gold nanoparticle conjugates as building blocks for the self-assembly of cross-linked particle layers", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US LNKD- DOI:10.1016/J.BBRC.2003.10.103, vol. 311, no. 4, 28 November 2003 (2003-11-28), pages 995 - 999, XP004472268, ISSN: 0006-291X
HURST SARAH J ET AL: "Maximizing DNA loading on a range of gold nanoparticle sizes", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US LNKD- DOI:10.1021/AC0613582, vol. 78, no. 24, 15 December 2006 (2006-12-15), pages 8313 - 8318, XP002465378, ISSN: 0003-2700
ZHANG ET AL: "A sensitive impedance immunosensor based on functionalized gold nanoparticle-protein composite films for probing apolipoprotein A-I", TALANTA, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/J.TALANTA.2006.05.081, vol. 71, no. 2, 20 January 2007 (2007-01-20), pages 874 - 881, XP022345637, ISSN: 0039-9140
MUKHERJEE S ET AL: "Monitoring cholesterol organization in membranes at low concentrations utilizing the wavelength-selective fluorescence approach", CHEMISTRY AND PHYSICS OF LIPIDS, LIMERICK, IR LNKD- DOI:10.1016/J.CHEMPHYSLIP.2004.12.001, vol. 134, no. 1, 1 March 2005 (2005-03-01), pages 79 - 84, XP004773921, ISSN: 0009-3084
THAXTON C SHAD ET AL: "Templated spherical high density lipoprotein nanoparticles.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 4 FEB 2009 LNKD- PUBMED:19133723, vol. 131, no. 4, 4 February 2009 (2009-02-04), pages 1384 - 1385, XP002587918, ISSN: 1520-5126
HURST SARAH J ET AL: "Maximizing DNA loading on a range of gold nanoparticle sizes", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US LNKD- DOI:10.1021/AC0613582, vol. 78, no. 24, 15 December 2006 (2006-12-15), pages 8313 - 8318, XP002465378, ISSN: 0003-2700
ZHANG ET AL: "A sensitive impedance immunosensor based on functionalized gold nanoparticle-protein composite films for probing apolipoprotein A-I", TALANTA, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/J.TALANTA.2006.05.081, vol. 71, no. 2, 20 January 2007 (2007-01-20), pages 874 - 881, XP022345637, ISSN: 0039-9140
MUKHERJEE S ET AL: "Monitoring cholesterol organization in membranes at low concentrations utilizing the wavelength-selective fluorescence approach", CHEMISTRY AND PHYSICS OF LIPIDS, LIMERICK, IR LNKD- DOI:10.1016/J.CHEMPHYSLIP.2004.12.001, vol. 134, no. 1, 1 March 2005 (2005-03-01), pages 79 - 84, XP004773921, ISSN: 0009-3084
THAXTON C SHAD ET AL: "Templated spherical high density lipoprotein nanoparticles.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 4 FEB 2009 LNKD- PUBMED:19133723, vol. 131, no. 4, 4 February 2009 (2009-02-04), pages 1384 - 1385, XP002587918, ISSN: 1520-5126
Attorney, Agent or Firm:
OYER, Timothy, J. (Greenfield & Sacks P.C.,Federal Reserve Plaza,600 Atlantic Avenu, Boston MA, US)
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