Title:
NANOVESICLES DERIVED FROM ACINETOBACTER BACTERIA AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/168329
Kind Code:
A1
Abstract:
The present invention relates to vesicles derived from Acinetobacter bacteria and a use thereof. The present inventors have confirmed experimentally that vesicles are significantly reduced in clinical samples derived from patients with malignant diseases such as gastric cancer, colorectal cancer, breast cancer, ovarian cancer, and bladder cancer, cardiovascular diseases such as myocardial infarction, cardiomyopathy, and stroke, diabetes mellitus, dementia, and Parkinson disease compared to a normal person, and the vesicles significantly inhibit secretion of an inflammatory mediator by pathogenic vesicles. The present inventors have confirmed that the vesicles have an anticancer effect in a mouse cancer model. Therefore, vesicles derived from Acinetobacter bacteria according to the present invention may be effectively used for developing a diagnostic method for malignant diseases such as gastric cancer, colorectal cancer, breast cancer, ovarian cancer, and bladder cancer, cardiovascular diseases such as myocardial infarction, cardiomyopathy, and stroke, diabetes mellitus, dementia, and Parkinson disease, and for developing a composition for preventing or treating the above-mentioned diseases or inflammatory diseases.
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Inventors:
KIM YOON-KEUN (KR)
Application Number:
PCT/KR2019/002343
Publication Date:
September 06, 2019
Filing Date:
February 27, 2019
Export Citation:
Assignee:
MD HEALTHCARE INC (KR)
International Classes:
C12Q1/689; A23L33/135; A61K35/74; A61P35/00; A61P37/00; C12Q1/6851
Foreign References:
| KR20180018354A | 2018-02-21 | |||
| KR20120114872A | 2012-10-17 | |||
| KR20160073157A | 2016-06-24 | |||
| KR20180006303A | 2018-01-17 | |||
| KR20160101521A | 2016-08-25 | |||
| KR101632896B1 | 2016-06-23 |
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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