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Patent Searching and Data


Title:
NANOVESICLES DERIVED FROM COLLINSELLA SP. BACTERIA, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/172604
Kind Code:
A1
Abstract:
The present invention relates to vesicles derived from Collinsella sp. bacteria, and a use thereof. The present inventors experimentally confirmed that: compared to those of a normal person, the vesicles are significantly reduced in clinical samples from patients with stomach cancer, pancreatic cancer, cholangiocarcinoma, ovarian cancer, bladder cancer, myocardial infarction, atrial fibrillation, chronic obstructive pulmonary disease (COPD), diabetes, mild cognitive impairment and Alzheimer's dementia; and when the vesicles isolated from a strain are administered, the secretion of inflammatory mediators by pathogenic vesicles, such as vesicles derived from Escherichia coli, is notably inhibited. Thus, the vesicles derived from Collinsella sp. bacteria, according to the present invention, may be usefully employed for the purpose of developing: a method for diagnosing stomach cancer, pancreatic cancer, cholangiocarcinoma, ovarian cancer, bladder cancer, myocardial infarction, atrial fibrillation, COPD, diabetes, mild cognitive impairment and Alzheimer's dementia; and a composition for preventing, treating or improving said diseases or inflammatory diseases accompanied by immune dysfunction.

Inventors:
KIM, Yoon-Keun (521-203, 70 Hanbit-ro,,Paju-Si, Gyeonggi-do, 10908, KR)
Application Number:
KR2019/002510
Publication Date:
September 12, 2019
Filing Date:
March 05, 2019
Export Citation:
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Assignee:
MD HEALTHCARE INC. (#1303, 9 World Cup buk-ro 56-gil,,Mapo-Gu, Seoul, 03923, KR)
International Classes:
C12Q1/689; C12Q1/6851; A23L33/135; A61K35/74; A61P35/00; A61P37/00
Attorney, Agent or Firm:
LEE, Myoung-Jin (6th floor, 28 Yeongdong-daero 85-gil,,Gangnam-Gu, Seoul, 06180, KR)
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