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Patent Searching and Data


Title:
NANOVESICLES DERIVED FROM GENUS BACILLUS BACTERIA AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/030732
Kind Code:
A1
Abstract:
The present invention relates to vesicles derived from the genus Bacillus bacteria and a use thereof. The present inventors have confirmed that the vesicles are significantly reduced in samples of patients with cancers, such as liver cancer, bladder cancer, breast cancer, and ovarian cancer; inflammatory diseases, such as asthma and atopic dermatitis; or metabolic diseases, such as diabetes and cirrhosis, compared with normal persons, and the vesicles inhibited the secretion of inflammatory mediators by pathogenic vesicles, such as E. coli-derived vesicles, which are causative factors of inflammatory diseases, diabetes, and the like. Therefore, the vesicles derived from the genus Bacillus bacteria according to the present invention can be advantageously used for the purpose of developing a diagnostic method for cancer, inflammatory diseases, and metabolic diseases, and a preventive or therapeutic composition therefor.

Inventors:
KIM YOON KEUN (KR)
Application Number:
PCT/KR2017/008497
Publication Date:
February 15, 2018
Filing Date:
August 07, 2017
Export Citation:
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Assignee:
MD HEALTHCARE INC (KR)
International Classes:
A61K35/742; A23L33/135; A61K8/99; A61K9/00; A61Q19/00
Foreign References:
KR20110025603A2011-03-10
KR20110025068A2011-03-09
KR20110082481A2011-07-19
KR20160110232A2016-09-21
Other References:
SCHERTZER, J. W. ET AL.: "Bacterial Outer Membrane Vesicles in Trafficking, Communication and the Host-pathogen Interaction", JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, vol. 23, no. 1-2, April 2013 (2013-04-01), pages 118 - 130, XP009185196
See also references of EP 3498285A4
CANCERS, vol. 6, 2014, pages 926 - 957
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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