Title:
NAPHTHALENE COMPOUNDS AND USE THEREOF AS DRUGS
Document Type and Number:
WIPO Patent Application WO/2003/024941
Kind Code:
A1
Abstract:
Naphthalene compounds represented by the general formula (1) or pharmaceutically acceptable salts, hydrates or solvates thereof, which exhibit anti−HIV activity and are useful in the treatment of AIDS: (1) wherein each symbol is as defined in the description.
Inventors:
INABA TAKASHI (JP)
KAYA TETSUDO (JP)
WATANABE WATARU (JP)
KAYA TETSUDO (JP)
WATANABE WATARU (JP)
Application Number:
PCT/JP2002/009587
Publication Date:
March 27, 2003
Filing Date:
September 18, 2002
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
INABA TAKASHI (JP)
KAYA TETSUDO (JP)
WATANABE WATARU (JP)
INABA TAKASHI (JP)
KAYA TETSUDO (JP)
WATANABE WATARU (JP)
International Classes:
C07D279/08; A61K31/453; A61K31/536; A61K31/537; A61K31/5415; A61K31/547; A61K31/553; A61K31/554; A61K45/00; A61P31/18; A61P43/00; C07D265/12; C07D267/16; C07D281/12; C07D491/107; C07D498/10; C07D498/20; C07D513/10; (IPC1-7): C07D265/12; A61K31/453; A61K31/536; A61K31/537; A61K31/5415; A61K31/547; A61K31/553; A61K31/554; A61K45/00; A61P31/18; A61P43/00; C07D267/16; C07D279/08; C07D281/12; C07D491/107; C07D498/10; C07D498/20; C07D513/10
Domestic Patent References:
| WO1995024408A1 | 1995-09-14 |
Foreign References:
| US4604388A | 1986-08-05 | |||
| JPH093055A | 1997-01-07 | |||
| EP0462522A1 | 1991-12-27 |
Other References:
HARVEY R.G. ET AL.: "A new chromone and flavone synthesis and its utilization for the synthesis of potentially antitumorigenic polycyclic chromones and flavones", J. ORG. CHEM., vol. 55, no. 25, 1990, pages 6161 - 6166, XP002960402
CLAYTON S.E. ET AL.: "Direct aromatic tert-butylation during the synthesis of thiochroman-4-ones", TETRAHEDRON, vol. 49, no. 4, 1993, pages 939 - 946, XP002028918
BONDAREV M. ET AL.: "Aryloxyethylamines as h5-HT1D serotonin receptor ligands", MED. CHEM. RES., vol. 8, no. 6, 1998, pages 333 - 342, XP002960403
TANDON V.K. ET AL.: "An improved two-step regioselective synthesis of naphth(1,2-b)- and naphth(2,1-b)oxepin-5-ones", SECTION B, vol. 37B, no. 10, 1998, pages 1027 - 1029, XP002960404
CLAYTON S.E. ET AL.: "Direct aromatic tert-butylation during the synthesis of thiochroman-4-ones", TETRAHEDRON, vol. 49, no. 4, 1993, pages 939 - 946, XP002028918
BONDAREV M. ET AL.: "Aryloxyethylamines as h5-HT1D serotonin receptor ligands", MED. CHEM. RES., vol. 8, no. 6, 1998, pages 333 - 342, XP002960403
TANDON V.K. ET AL.: "An improved two-step regioselective synthesis of naphth(1,2-b)- and naphth(2,1-b)oxepin-5-ones", SECTION B, vol. 37B, no. 10, 1998, pages 1027 - 1029, XP002960404
Attorney, Agent or Firm:
Takashima, Hajime (2-14 Fushimimachi 4-chome, Chuo-k, Osaka-shi Osaka, JP)
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