Title:
NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS
Document Type and Number:
WIPO Patent Application WO2000071506
Kind Code:
A9
Abstract:
Compounds of formula (I), wherein R<1> and R<2> are substituents on the A rings and are, independently, -SO2NR<7>2, -C(O)NR<7>2, -NR<7>SO2R<7>, -NR<7>C(O)R<7>, -SO2OR<7>, -C(O)OR<7>, -OSO2R<7>, or -OC(O)R<7>, R<3> and R<4> are, independently, hydrogen or lower alkyl, or R<3> and R<4> together are -(CH2)2-, -(CH2)3-, or -(CH2)4-, or R<3> or R<4> may be an electron pair, R<5> and R<6> are, independently, hydrogen, alkyl, substituted alkyl, cyano, halo, nitro, -SR<8>, -C(O)R<8>, -SO2OR<8>, -OSO2R<8>, -SO2NR<8>2, -NR<8>SO2R<8>, -OC(O)R<8>, -C(O)OR<8>, -C(O)NR<8>2, -NR<8>C(O)R<8>, -OR<8>, or -NR<8>2, each R<7> and R<8> is, independently, hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, aryl(lower)alkyl, substituted aryl(lower)alkyl, heteroaryl(lower)alkyl, substituted heteroaryl(lower)alkyl, heterocyclyl, substituted heterocyclyl, heteroaryl, or substituted heteroaryl, each Y is, independently, a non-interfering substituent which is not linked to the naphthalene ring via an azo or amide linkage, each x is independently, 0, 1 or 2, and the linker connects a carbon designated as c to a carbon designated as d, or a pharmaceutically acceptable salt thereof, as a single stereoisomer or mixture of stereoisomers, are useful for treating conditions associated with hyperglycemia, especially Type II diabetes, with dinaphthylureas. These compounds are useful in stimulating the kinase activity of the insulin receptor, activating the insulin receptor, and stimulating the uptake of glucose. Pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.
Inventors:
SPEVAK WAYNE
LUM ROBERT T
SHI SONGYUAN
MANCHEM PRASAD
KOZLOWSKI MICHAEL R
SCHOW STEVEN R
LUM ROBERT T
SHI SONGYUAN
MANCHEM PRASAD
KOZLOWSKI MICHAEL R
SCHOW STEVEN R
Application Number:
PCT/US2000/014644
Publication Date:
September 20, 2001
Filing Date:
May 25, 2000
Export Citation:
Assignee:
TELIK INC (US)
International Classes:
A61K31/18; A61K31/216; A61K31/255; A61K31/41; A61K31/4166; A61K31/4406; A61K31/445; A61K31/4965; A61K31/505; A61K31/662; C07D233/32; A61P3/10; A61P43/00; C07B59/00; C07C273/00; C07C275/42; C07C303/22; C07C303/30; C07C303/38; C07C309/51; C07C309/58; C07C309/76; C07C309/88; C07C311/21; C07C311/47; C07C335/16; C07C335/18; C07C335/32; C07D211/60; C07D211/96; C07D213/76; C07D233/36; C07D239/42; C07D241/20; C07D257/04; C07F9/40; (IPC1-7): C07C311/47; C07C309/51; C07D257/04; C07D213/76; C07D233/32; C07D335/18; C07C335/32; C07D211/96; A61K31/18; A61K31/395
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