NAPHTHALIMIDE DERIVATIVES AS ANTIVIRAL AGENTS - ELETTI SPA ISTITUTO DI RICERCH

Title:

NAPHTHALIMIDE DERIVATIVES AS ANTIVIRAL AGENTS

Document Type and Number:

WIPO Patent Application WO2006027628

Kind Code:

A3

Abstract:

The present invention relates to the use of naphthalimide compounds of formula (I), wherein A, B, R¹, R², n and R^a are defined herein, and pharmaceutically acceptable salts thereof, for the treatment or prevention of infection by hepatitis C virus.

Inventors:

CARROLL STEVE (US)
HERNANDO JOSE IGNACIO MARTIN (IT)
MALANCONA SAVINA (IT)
MIGLIACCIO GIOVANNI (IT)
NARJES FRANK (IT)
OLSEN DAVID (US)
ONTORIA ONTORIA JESUS MARIA (IT)
ROWLEY MICHAEL (IT)
SUMMA VINCENZO (IT)

Application Number:

PCT/GB2005/050145

Publication Date:

May 04, 2006

Filing Date:

September 07, 2005

Export Citation:

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Assignee:

ELETTI SPA ISTITUTO DI RICERCH (IT)
MERCK & CO INC (US)
CARROLL STEVE (US)
HERNANDO JOSE IGNACIO MARTIN (IT)
MALANCONA SAVINA (IT)
MIGLIACCIO GIOVANNI (IT)
NARJES FRANK (IT)
OLSEN DAVID (US)
ONTORIA ONTORIA JESUS MARIA (IT)
ROWLEY MICHAEL (IT)
SUMMA VINCENZO (IT)

International Classes:

A61K31/473; A61K31/506; A61K31/519; A61K31/5377; A61P31/14; C07D221/14; C07D401/04; C07D401/06; C07D401/12; C07D405/04; C07D405/12; C07D409/12; C07D409/14; C07D413/06; C07D417/04; C07D417/12; C07D417/14; C07D453/06; C07D487/04

Domestic Patent References:

WO2000031039A1	2000-06-02
WO2003101998A1	2003-12-11
WO2000055118A1	2000-09-21

Foreign References:

EP0930883B1	2006-01-11
US5235045A	1993-08-10
EP0733365A2	1996-09-25
US5789434A	1998-08-04

Other References:

COSTI M ET AL: "Naphthalimido derivatives as antifolate thymidylate synthase inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 31, no. 12, 1996, pages 1011 - 1016, XP004071796, ISSN: 0223-5234

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