NAPHTHALIMIDE DOSING BY N-ACETYL TRANSFERASE GENOTYPING

Title:

NAPHTHALIMIDE DOSING BY N-ACETYL TRANSFERASE GENOTYPING

Document Type and Number:

WIPO Patent Application WO2005074599

Kind Code:

A3

Abstract:

The present invention provides methods for dosing patients with naphthalimides, including amonafide, amonafide salts, and analogs thereof based on N-acetyl transferase genotyping. The invention also provides methods for dosing the amount of granulocyte colony stimulating factor (GCSF) used in combination with naphthalimide to prevent or modulate leukocytopenia.

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Inventors:

BROWN DENNIS M (US)

Application Number:

PCT/US2005/003187

Publication Date:

June 08, 2006

Filing Date:

January 31, 2005

Export Citation:

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Assignee:

CHEMGENEX THERAPEUTICS INC (US)
BROWN DENNIS M (US)

International Classes:

C12Q1/68; A61K31/435; A61K31/473; C07H21/04

Other References:

PRICE EVANS D A.: "N-Acetyltransferase.", PHARMAC THER., vol. 42, 1989, pages 157 - 134, XP002996516
HEIN D W ET AL: "Molecular Genetics and Epidemiology of the NAT1 and NAT2 Acetylation Polymorphisms.", CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION., vol. 9, January 2000 (2000-01-01), pages 29 - 42, XP002996517

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