NATURAL ANTI-ANGIOGENIC COMPOSITION, METHOD OF PREPARATION THEREOF AND ITS APPLICATION

Title:

NATURAL ANTI-ANGIOGENIC COMPOSITION, METHOD OF PREPARATION THEREOF AND ITS APPLICATION

Document Type and Number:

WIPO Patent Application WO/2002/053165

Kind Code:

A1

Abstract:

The invention provides a kind of natural anti-angiogenic composition, method for preparation thereof and its application in angiogenic inhibitor and antitumor drug. The composition can be obtained by extracting Radix trichosanthis in solvent at normal temperature and pressure, subjecting the extract to a treatment with a kind of solvent and separating the obtained carbohydrates by column chromatography at least one time. By the means of anti-angiogensis assay in vivo, cell culture assay in vitro, and animal antitumor assay, the active ingredient extracted from radix trichosanthis according to the invention has been demonstrated anti-angiogenic and antitumor activity.

Inventors:

KE YANG (CN)
LU GUIRONG (CN)
WANG YUEQI (CN)
PANG HE (CN)
NING TAO (CN)

Application Number:

PCT/CN2000/000740

Publication Date:

July 11, 2002

Filing Date:

December 29, 2000

Export Citation:

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Assignee:

BEIJING INSITITUTE FOR CANCER (CN)
KE YANG (CN)
LU GUIRONG (CN)
WANG YUEQI (CN)
PANG HE (CN)
NING TAO (CN)

International Classes:

A61K36/00; A61K36/428; A61P35/00; (IPC1-7): A61K35/78; A61P35/00

Foreign References:

CN1046680A	1990-11-07
KR940001730B1	1994-03-05
CN1173995A	1998-02-25
US5910307A	1999-06-08

Other References:

GUO FENG ET AL.: "The effect of radix trichosanthis on immunologic function of human erythrocyte", JOURNAL OF THE PLA'S MEDICINE, vol. 23, no. 5, 1998, pages 455 - 457

Attorney, Agent or Firm:

BEIJING SANYOU PATENT AGENCY CO., LTD. (Beijing 4, CN)

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