Title:
NAV1.7 MONOCLONAL ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2019/230856
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel Nav1.7 monoclonal antibody. Disclosed is a Nav1.7 monoclonal antibody having six specific CDRs (heavy-chain CDR1 through CDR3 and light-chain CDR1 through CDR3) or a specific heavy-chain variable region/light-chain variable region, or an antibody fragment of the Nav1.7 monoclonal antibody. The monoclonal antibody, etc., can be used in the treatment or prevention of pain, pruritus, etc.
Inventors:
TAKAHASHI TATSUYA (JP)
KODAMA MAI (JP)
YONEDA SOSUKE (JP)
ONODA JUNJI (JP)
NAKAMURA ETSUO (JP)
MIYAUCHI TSUGUO (JP)
ASAKI TOSHIYUKI (JP)
KASAI ERIKA (JP)
KODAMA MAI (JP)
YONEDA SOSUKE (JP)
ONODA JUNJI (JP)
NAKAMURA ETSUO (JP)
MIYAUCHI TSUGUO (JP)
ASAKI TOSHIYUKI (JP)
KASAI ERIKA (JP)
Application Number:
PCT/JP2019/021444
Publication Date:
December 05, 2019
Filing Date:
May 30, 2019
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C12N15/13; A61K39/395; A61P25/02; C07K16/18; C12N15/63; C12P21/08
Domestic Patent References:
| WO2011051350A1 | 2011-05-05 | |||
| WO2014159595A2 | 2014-10-02 | |||
| WO2015032916A1 | 2015-03-12 | |||
| WO2015035173A1 | 2015-03-12 | |||
| WO1995014041A1 | 1995-05-26 | |||
| WO1996002576A1 | 1996-02-01 | |||
| WO1998013388A1 | 1998-04-02 |
Foreign References:
| JP2013507980A | 2013-03-07 | |||
| JP2016512430A | 2016-04-28 | |||
| US8734798B2 | 2014-05-27 | |||
| US8986954B2 | 2015-03-24 | |||
| US9266953B2 | 2016-02-23 |
Other References:
PNAS, vol. 94, 1997, pages 1527 - 1532
PNAS, vol. 101, 2004, pages 12706 - 12711
PAIN, vol. 153, no. 1, 2012, pages 80 - 85
THE LANCET NEUROLOGY, vol. 16, no. 4, 2017, pages 291 - 300
"Molecular Cloning, A Laboratory Manual", 2012, COLD SPRING HARBOR LABORATORY PRESS
EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 6, no. 5, 1996, pages 441 - 456
REITER ET AL., PROTEIN ENGINEERING, vol. 7, 1994, pages 697
SATO ET AL., CANCER RES., vol. 53, 1993, pages 851
CLINICAL CANCER RESEARCH, vol. 10, 2004, pages 1274 - 1281
SAMBROOK, J ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LAB. PRESS
WILBUR, W. J.LIPMAN, D. J., PROC. NATL. ACAD. SCI. USA, vol. 80, 1983, pages 726 - 730
WU, T. T.KABAT, E. A., J EXP. MED., vol. 132, no. 2, 1970, pages 211 - 50
See also references of EP 3805390A4
PNAS, vol. 101, 2004, pages 12706 - 12711
PAIN, vol. 153, no. 1, 2012, pages 80 - 85
THE LANCET NEUROLOGY, vol. 16, no. 4, 2017, pages 291 - 300
"Molecular Cloning, A Laboratory Manual", 2012, COLD SPRING HARBOR LABORATORY PRESS
EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 6, no. 5, 1996, pages 441 - 456
REITER ET AL., PROTEIN ENGINEERING, vol. 7, 1994, pages 697
SATO ET AL., CANCER RES., vol. 53, 1993, pages 851
CLINICAL CANCER RESEARCH, vol. 10, 2004, pages 1274 - 1281
SAMBROOK, J ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LAB. PRESS
WILBUR, W. J.LIPMAN, D. J., PROC. NATL. ACAD. SCI. USA, vol. 80, 1983, pages 726 - 730
WU, T. T.KABAT, E. A., J EXP. MED., vol. 132, no. 2, 1970, pages 211 - 50
See also references of EP 3805390A4
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
Download PDF:
Previous Patent: CATALYST, METHOD FOR REDUCING CARBON DIOXIDE, AND APPARATUS FOR REDUCING CARBON DIOXIDE
Next Patent: POLYCYCLIC PYRIDONE DERIVATIVE
Next Patent: POLYCYCLIC PYRIDONE DERIVATIVE