Title:
NEOANTIGEN IDENTIFICATION METHOD AND DEVICE FOR TUMOR-SPECIFIC CIRCULAR RNAS, APPARATUS AND MEDIUM
Document Type and Number:
WIPO Patent Application WO/2024/051097
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of bioinformatics. Disclosed in the present invention is a neoantigen identification method for tumor-specific circular RNAs. The method comprises: for candidate circular RNAs that have been detected, constructing pseudo-reference sequences for realignment, respectively aligning sequencing data of tumor tissue samples and paracancerous tissue samples to the pseudo-reference sequences, extracting determined first candidate reads and second candidate reads after alignment, determining candidate circular RNAs supported by the first candidate reads as first circular RNAs in the tumor tissues and candidate circular RNAs supported by the second candidate reads as second circular RNAs in the paracancerous tissues, fusing the first circular RNAs and the second circular RNAs, filtering the circular RNAs, which are present in both the tumor tissues and the paracancerous tissues, to obtain tumor-specific circular RNAs, further predicting a translation ability score, and scoring and ranking neoantigens derived from the circular RNAs to obtain top-ranked neoantigens. In the present invention, sources of tumor neoantigens can be increased, the identification accuracy of circular RNAs can also be improved, and the neoantigens thereof are more immunogenic.
Inventors:
WAN JI (CN)
WANG JIAN (CN)
ZHAO ZHAO (CN)
PAN YOUDONG (CN)
WANG YI (CN)
WANG JIAN (CN)
ZHAO ZHAO (CN)
PAN YOUDONG (CN)
WANG YI (CN)
Application Number:
PCT/CN2023/077356
Publication Date:
March 14, 2024
Filing Date:
February 21, 2023
Export Citation:
Assignee:
SHENZHEN NEOCURNA BIOTECHNOLOGY CORP (CN)
NEOCURA BIO MEDICAL TECH CO LTD (CN)
BEIJING NEOCURNA BIOTECHNOLOGY CORP (CN)
NEOCURA BIO MEDICAL TECH CO LTD (CN)
BEIJING NEOCURNA BIOTECHNOLOGY CORP (CN)
International Classes:
G16B30/10; G16B35/10
Foreign References:
| CN115240773A | 2022-10-25 | |||
| US20190279742A1 | 2019-09-12 | |||
| CN111192632A | 2020-05-22 | |||
| EP3618071A1 | 2020-03-04 | |||
| CN109801678A | 2019-05-24 | |||
| CN113035272A | 2021-06-25 | |||
| CN114882951A | 2022-08-09 | |||
| CN111584006A | 2020-08-25 | |||
| US20220112556A1 | 2022-04-14 | |||
| CN111627497A | 2020-09-04 |
Attorney, Agent or Firm:
GUANGZHOU PRIME IP LAW OFFICE (CN)
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