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Title:
NEOPETROSIDES A AND B, AND SYNTHESIS METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/209494
Kind Code:
A1
Abstract:
The present invention relates to Neopetroside A (NPS A) and Neopetroside B (NPS B), which are novel pyridine nucleoside compounds obtained by fractioning an ethanol extract of Neopetrosia sp., a marine sponge, with n-butanol (n-BuOH). When applied to myocardial cells, NPS A exhibits the effect of activating oxidative phosphorylation, basal and mitochondrial oxygen consumption rates, ATP-linked respiration, and ATP synthesis, and stimulating glycolysis. When applied to an ischemia reperfusion injury model, NPS A showed the effect of recuperating a left ventricle pressure damaged by ischemia reperfusion and significantly reducing the size of a myocardial injury region. Thus, the compound may be provided as a pharmaceutical composition for the prevention or treatment of ischemia cardiac diseases or as a health functional food for the prevention or amelioration of ischemia cardiac diseases.

Inventors:
HAN, Jin (121-1804, 200 Gobun-ro,Yeonje-gu, Busan, 47585, KR)
JEONG, Seung Hun (100 Geumjeongmaeul-ro, Dongnae-gu, Busan, 47718, KR)
SONG, In-Sung (107-203, 9 Geumo 15-gil, Dong-myeon,Yangsan-si, Gyeongsangnam-do, 50651, KR)
KIM, Hyoung Kyu (103-807, 34 Gaegeumbondong-ro,Busanjin-gu, Busan, 47168, KR)
KIM, Nari (101-703, 25 Centum dong-ro,Haeundae-gu, Busan, 48059, KR)
SHUBINA, Larisa K. (G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences Prospect 100-let Vladivostoku 15, Vladivostok 2, 690022, RU)
MAKARIEVA, Tatyana N. (G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences Prospect 100-let Vladivostoku 15, Vladivostok 2, 690022, RU)
STONIK, Valentin A. (G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences Prospect 100-let Vladivostoku 15, Vladivostok 2, 690022, RU)
YASHUNSKY, Dmitry V. (N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, Leninsky Prospect 4, Moscow 1, 119991, RU)
NIFANTIEV, Nikolay E. (N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, Leninsky Prospect 4, Moscow 1, 119991, RU)
Application Number:
KR2017/005645
Publication Date:
December 07, 2017
Filing Date:
May 30, 2017
Export Citation:
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Assignee:
INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (197 Inje-ro, Gimhae-si, Gyeongsangnam-do, 50834, KR)
International Classes:
C07D405/04; A23L33/10; A61K31/443; C07D405/14
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (#601 Innoplex 1 cha, 151Gasandigital 1-roGeumcheon-gu, Seoul, 08506, KR)
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