Title:
NEOPLASM SPECIFIC ANTIBODIES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2003076472
Kind Code:
A3
Abstract:
The present invention features polypeptides, such as antibodies, and their use in the treatment and diagnosis of neoplasms.
Inventors:
VOLLMERS HEINZ PETER (DE)
MUELLER-HERMELINK HANS KONRAD (DE)
MUELLER-HERMELINK HANS KONRAD (DE)
Application Number:
PCT/IB2003/001335
Publication Date:
March 25, 2004
Filing Date:
March 10, 2003
Export Citation:
Assignee:
ONCOMAB GMBH (DE)
VOLLMERS HEINZ PETER (DE)
MUELLER-HERMELINK HANS KONRAD (DE)
VOLLMERS HEINZ PETER (DE)
MUELLER-HERMELINK HANS KONRAD (DE)
International Classes:
A61K47/48; A61P35/00; C07K16/30; C12N5/28; C12N15/08; C12N15/13; G01N33/574; (IPC1-7): C07K16/30; C12N5/28; C12N15/08; G01N33/574; G01N33/577; A61K51/10; A61K39/395; A61K47/48; A61P35/00
Domestic Patent References:
| WO2001083560A1 | 2001-11-08 | |||
| WO1997013844A1 | 1997-04-17 | |||
| WO2001062932A1 | 2001-08-30 |
Foreign References:
| EP1106183A2 | 2001-06-13 |
Other References:
BRAENDLEIN STEPHANIE ET AL: "Characterization of five new fully human monoclonal IgM antibodies isolated from carcinoma patients", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 43, March 2002 (2002-03-01), 93rd Annual Meeting of the American Association for Cancer Research;San Francisco, California, USA; April 06-10, 2002, March, 2002, pages 970, XP001155782, ISSN: 0197-016X
BRAENDLEIN STEPHANIE ET AL: "Human monoclonal IgM antibodies with apoptotic activity isolated from cancer patients.", HUMAN ANTIBODIES, vol. 11, no. 4, 2002, pages 107 - 119, XP009020163, ISSN: 1093-2607
MENG RAYMOND D ET AL: "p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma", EXPERIMENTAL CELL RESEARCH, vol. 262, no. 2, 15 January 2001 (2001-01-15), pages 154 - 169, XP002260126, ISSN: 0014-4827
HUANG YING ET AL: "Sulindac sulfide-induced apoptosis involves death receptor 5 and the caspase 8-dependent pathway in human colon and prostate cancer cells", CANCER RESEARCH, vol. 61, no. 18, 15 September 2001 (2001-09-15), pages 6918 - 6924, XP002260127, ISSN: 0008-5472
BRAENDLEIN STEPHANIE ET AL: "Human monoclonal IgM antibodies with apoptotic activity isolated from cancer patients.", HUMAN ANTIBODIES, vol. 11, no. 4, 2002, pages 107 - 119, XP009020163, ISSN: 1093-2607
MENG RAYMOND D ET AL: "p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma", EXPERIMENTAL CELL RESEARCH, vol. 262, no. 2, 15 January 2001 (2001-01-15), pages 154 - 169, XP002260126, ISSN: 0014-4827
HUANG YING ET AL: "Sulindac sulfide-induced apoptosis involves death receptor 5 and the caspase 8-dependent pathway in human colon and prostate cancer cells", CANCER RESEARCH, vol. 61, no. 18, 15 September 2001 (2001-09-15), pages 6918 - 6924, XP002260127, ISSN: 0008-5472
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