Title:
NEOVASCULAR-TARGETING CONTRAST MEDIUM COMPOSITION AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2020/022765
Kind Code:
A1
Abstract:
The present invention relates to a neovascular-targeting contrast medium composition and a method for preparing same. The neovascular-targeting contrast medium composition according to the present invention exhibits high binding force to neovascularization-associated αvβ3 integrin, excellent tissue permeability and biostability, enables simple measurement in vitro, in vivo, or ex vivo, and thus is effective in the detection of neovascularization and in diagnosing diseases associated therewith, and therefore can be usefully employed in the relevant industries.
Inventors:
CHANG KI-YUK (KR)
PARK HYO-EUN (KR)
KIM EUN-MIN (KR)
PARK EUN-HYE (KR)
KIM CHAN-WOO (KR)
KANG KWON-YOON (KR)
HONG KWAN-SOO (KR)
LEE HYUN-SEUNG (KR)
KIM HYUN-MIN (KR)
PARK HYO-EUN (KR)
KIM EUN-MIN (KR)
PARK EUN-HYE (KR)
KIM CHAN-WOO (KR)
KANG KWON-YOON (KR)
HONG KWAN-SOO (KR)
LEE HYUN-SEUNG (KR)
KIM HYUN-MIN (KR)
Application Number:
PCT/KR2019/009147
Publication Date:
January 30, 2020
Filing Date:
July 24, 2019
Export Citation:
Assignee:
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
KOREA BASIC SCIENCE INST (KR)
KOREA BASIC SCIENCE INST (KR)
International Classes:
A61K51/10; C07K16/28
Foreign References:
| US9694089B2 | 2017-07-04 | |||
| CN103191447A | 2013-07-10 |
Other References:
BASULI, F. ET AL.: "Fast indirect fluorine-1 8 labeling of protein/peptide using the useful 6-fluoronicotinic acid-2,3,5,6-tetrafluorophenyl prosthetic group: A method comparable to direct fluorination", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 60, no. 3, March 2017 (2017-03-01), pages 168 - 175, XP055681649
HWANG, M.-H. ET AL.: "Biological production of an integrin alphanubeta3 targeting imaging probe and functional verification BioMed research international", BIOMED RESEARCH INTERNATIONAL, vol. 2015, 2015, pages 1 - 8, XP055780365
IEZZI, M. E. ET AL.: "Single-domain antibodies and the promise of modular targeting in cancer imaging and treatment . Frontiers in immunology", THESIS NO:273, vol. 9, 19 February 2018 (2018-02-19), pages 1 - 11, XP055473497
DAVID A CHERESH ET AL., NATURE MEDICINE, vol. 15, no. 10, 2009, pages 1163
HAMERS-CASTERMAN, C. ET AL., NATURE, vol. 363, 1993, pages 446 - 448
CORTEZ-RETAMOZO, V. ET AL., CANCER RES., vol. 64, 2004, pages 2853 - 2857
ARBABI-GHAHROUDII, M. ET AL., FEBS LETT., vol. 414, 1997, pages 521 - 526
DUMOULIN, M. ET AL., PROTEIN SCIII., vol. 11, 2002, pages 500 - 515
DUMOULIN, M. ET AL., NATURE, vol. 424, 2003, pages 783 - 788
See also references of EP 3834850A4
HWANG, M.-H. ET AL.: "Biological production of an integrin alphanubeta3 targeting imaging probe and functional verification BioMed research international", BIOMED RESEARCH INTERNATIONAL, vol. 2015, 2015, pages 1 - 8, XP055780365
IEZZI, M. E. ET AL.: "Single-domain antibodies and the promise of modular targeting in cancer imaging and treatment . Frontiers in immunology", THESIS NO:273, vol. 9, 19 February 2018 (2018-02-19), pages 1 - 11, XP055473497
DAVID A CHERESH ET AL., NATURE MEDICINE, vol. 15, no. 10, 2009, pages 1163
HAMERS-CASTERMAN, C. ET AL., NATURE, vol. 363, 1993, pages 446 - 448
CORTEZ-RETAMOZO, V. ET AL., CANCER RES., vol. 64, 2004, pages 2853 - 2857
ARBABI-GHAHROUDII, M. ET AL., FEBS LETT., vol. 414, 1997, pages 521 - 526
DUMOULIN, M. ET AL., PROTEIN SCIII., vol. 11, 2002, pages 500 - 515
DUMOULIN, M. ET AL., NATURE, vol. 424, 2003, pages 783 - 788
See also references of EP 3834850A4
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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