Title:
NEOVASCULARIZATION INHIBITORS
Document Type and Number:
WIPO Patent Application WO/1999/034795
Kind Code:
A1
Abstract:
Cyclic disulfide derivatives represented by general formula (I), wherein R?1¿, R?2¿ and R?3¿ represent each H or alkyl; m is 0 or 1, and n is 1 or 2. Because of having effects of inhibiting neovascularization, regulating vascular permeability and preventing vascular endothelial growth factor from releasing, these compounds are expected as being useful as remedies for diseases in which neovascularization, vascular permeability or vascular endothelial growth factor participates, in particular, retinal diseases such as diabetic retinopathy, macular degeneration, retinal venous obliteration and retinal arterial obliteration, neovascularization glaucoma and tumors such as anginoma.
Inventors:
MITA SHIRO (JP)
MATSUOKA HIDEHITO (JP)
MATSUOKA HIDEHITO (JP)
Application Number:
PCT/JP1999/000018
Publication Date:
July 15, 1999
Filing Date:
January 07, 1999
Export Citation:
Assignee:
SANTEN PHARMACEUTICAL CO LTD (JP)
MITA SHIRO (JP)
MATSUOKA HIDEHITO (JP)
MITA SHIRO (JP)
MATSUOKA HIDEHITO (JP)
International Classes:
C07D285/38; (IPC1-7): A61K31/395; A61K31/55
Foreign References:
| JPH02138271A | 1990-05-28 | |||
| JPH04208271A | 1992-07-29 | |||
| JPS5592315A | 1980-07-12 |
Attorney, Agent or Firm:
Kishimoto, Einosuke (3rd floor 13-18, Nishishinsaibashi 1-chome Chuo-ku Osaka-shi Osaka, JP)
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