Title:
NEOVASCULARIZATION PROMOTERS
Document Type and Number:
WIPO Patent Application WO/1999/009992
Kind Code:
A1
Abstract:
Neovascularization promoters which contain as the active ingredient compounds represented by general formula (I), wherein R?1¿ represents acyl; R?2¿ represents alkyl; R?3¿ and R?4¿ are the same or different and each represents hydrogen or a hydroxy-protective group; and R?5¿ represents alkyl. These compounds not only have the effect of promoting neovascularization by themselves but also potentiate neovascularization by drugs having neovascularizing effects such as b-FGF. Therefore, there compounds can potentiate the neovascularization in an ischemic tissue or at a site where b-FGF is locally increased due to other pathological factors.
Inventors:
EGI YASUHIRO (JP)
KUBO YOSHIJI (JP)
INOUE SATORU (JP)
KIDO HIDEAKI (JP)
NISHIKAWA MASAKUNI (JP)
HAYASHI KAZUTAKA (JP)
KUBO YOSHIJI (JP)
INOUE SATORU (JP)
KIDO HIDEAKI (JP)
NISHIKAWA MASAKUNI (JP)
HAYASHI KAZUTAKA (JP)
Application Number:
PCT/JP1998/003754
Publication Date:
March 04, 1999
Filing Date:
August 24, 1998
Export Citation:
Assignee:
YOSHITOMI PHARMACEUTICAL (JP)
SEIKAGAKU KOGYO CO LTD (JP)
MIZUSHIMA YUTAKA (JP)
EGI YASUHIRO (JP)
KUBO YOSHIJI (JP)
INOUE SATORU (JP)
KIDO HIDEAKI (JP)
NISHIKAWA MASAKUNI (JP)
HAYASHI KAZUTAKA (JP)
SEIKAGAKU KOGYO CO LTD (JP)
MIZUSHIMA YUTAKA (JP)
EGI YASUHIRO (JP)
KUBO YOSHIJI (JP)
INOUE SATORU (JP)
KIDO HIDEAKI (JP)
NISHIKAWA MASAKUNI (JP)
HAYASHI KAZUTAKA (JP)
International Classes:
A61K31/557; A61K31/5575; A61K38/18; A61K45/06; (IPC1-7): A61K31/557
Foreign References:
| JPH05213862A | 1993-08-24 | |||
| JPH03204853A | 1991-09-06 |
Other References:
ZICHE M, ET AL.: "ANGIOGENESIS CAN BE STIMULATED OR REPRESSED IN VIVO BY A CHANGE IN GM3:GD3 GANGLIOSIDE RATIO", LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP, THE UNITED STATES AND CANADIAN ACADEMY OF PATHOLOGY, INC., vol. 67, no. 06, 1 January 1992 (1992-01-01), The United States and Canadian Academy of Pathology, Inc., pages 711 - 715, XP002918640, ISSN: 0023-6837
ZICHE M, ALESSANDRI G, GULLINO P M: "GANGLIOSIDES PROMOTE THE ANGIOGENIC RESPONSE", LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP, THE UNITED STATES AND CANADIAN ACADEMY OF PATHOLOGY, INC., vol. 61, no. 06, 1 January 1989 (1989-01-01), The United States and Canadian Academy of Pathology, Inc., pages 629 - 634, XP002918641, ISSN: 0023-6837
See also references of EP 1008349A4
ZICHE M, ALESSANDRI G, GULLINO P M: "GANGLIOSIDES PROMOTE THE ANGIOGENIC RESPONSE", LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP, THE UNITED STATES AND CANADIAN ACADEMY OF PATHOLOGY, INC., vol. 61, no. 06, 1 January 1989 (1989-01-01), The United States and Canadian Academy of Pathology, Inc., pages 629 - 634, XP002918641, ISSN: 0023-6837
See also references of EP 1008349A4
Attorney, Agent or Firm:
Takashima, Hajime (Hiranomachi 3-chome Chuo-ku Osaka-shi Osaka, JP)
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