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Title:
NERVE CELL CULTURE MATERIAL AND THERAPEUTIC AGENT FOR NERVE DAMAGE
Document Type and Number:
WIPO Patent Application WO/2019/151450
Kind Code:
A1
Abstract:
When performing actual transplantation into a body for the purpose of regenerative medicine, advanced safety measures are necessary in sterilization treatment or the packaging process, and a large burden is placed on a practitioner when a new material is to be utilized. Meanwhile, conventional collagen is even now being utilized for implantation in other applications, and the results of transplantation thereof are good. However, conventional collagen has not been shown to work effectively for curing nerve damage. Conventional LASCol has not been known to have a survival-maintaining effect on nerve cells. The nerve cell culture material including LASCol according to the present invention has the effect of suitably maintaining survival of nerve cells. The therapeutic agent for nerve cell damage including LASCol according to the present invention permeates or advantageously causes proliferation of endogenous nerve cells even in a living body, thereby enabling early extension and connection of neurites, and has an effect sufficient to produce an improved BBB score with respect to nerve damage.

Inventors:
MORIMOTO Koichi (KINKI UNIVERSITY 930 Nishimitani, Kinokawa Cit, Wakayama 93, 〒6496493, JP)
KUNII Saori (KINKI UNIVERSITY 930 Nishimitani, Kinokawa Cit, Wakayama 93, 〒6496493, JP)
KANEKIYO Kenji (1-22 Takada-cho, Ibaraki-sh, Osaka 11, 〒5670011, JP)
NAKANO Norihiko (1-22 Takada-cho, Ibaraki-sh, Osaka 11, 〒5670011, JP)
IDE Chizuka (1-22 Takada-cho, Ibaraki-sh, Osaka 11, 〒5670011, JP)
OMAE Kaoru (Minatojima Minamimachi Chuo-ku, Kobe-sh, Hyogo 47, 〒6500047, JP)
Application Number:
JP2019/003502
Publication Date:
August 08, 2019
Filing Date:
January 31, 2019
Export Citation:
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Assignee:
KINKI UNIVERSITY (3-4-1, Kowakae Higashiosaka Cit, Osaka 02, 〒5778502, JP)
AINO UNIVERSITY (1-22, Takada-cho Ibaraki-sh, Osaka 11, 〒5670011, JP)
FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBE (2-2 Minatojima Minamimachi, Chuo-ku Kobe-sh, Hyogo 47, 〒6500047, JP)
International Classes:
C12M3/00; A61K38/01; A61P7/00; A61P25/00; A61P43/00; C12N5/0793; A61K38/39; C07K14/78; C12N15/09
Domestic Patent References:
WO2015167004A12015-11-05
WO2015167003A12015-11-05
Foreign References:
JP2007177074A2007-07-12
Attorney, Agent or Firm:
HIROKOH Masaki (Tatsuno Nishi-Tenma Bldg, 1-6 Nishi-Tenma 3-chome, Kita-ku, Osaka-sh, Osaka 47, 〒5300047, JP)
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