Title:
NERVE CELL CULTURING PLATFORM COATED WITH FUNCTIONAL POLYMER THIN FILM, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/069429
Kind Code:
A1
Abstract:
The present invention relates to: a nerve cell culturing platform coated with a functional polymer thin film; and a use thereof and, more specifically, to: a nerve cell culturing platform manufactured by coating a first thin film on a substrate by using initiated chemical vapor deposition (iCVD), and layering a positively charged biomimetic second thin film thereon; or a nerve cell culturing platform manufactured by coating a positively charged monolayered biomimetic thin film on a substrate by using iCVD; and a nerve cell culturing method using the same. The nerve cell culturing platform can be developed by effectively depositing a biomimetic thin film having a cell compatible function on various types of substrates through a method for manufacturing a nerve cell culturing platform according to the present invention. Particularly, if the nerve cell culturing platform of the present invention is used, growth promotion and stable long-term culturing of nerve cells, which are difficult to be cultured, are enabled, and thus the nerve cell culturing platform can contribute to research on nerve cell-related diseases and to basic research.
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Inventors:
IM SUNG GAP (KR)
JON SANGYONG (KR)
BAEK JIEUNG (KR)
YU SEUNGYOON (KR)
CHOI MINSUK (KR)
LEE HAK RAE (KR)
JON SANGYONG (KR)
BAEK JIEUNG (KR)
YU SEUNGYOON (KR)
CHOI MINSUK (KR)
LEE HAK RAE (KR)
Application Number:
PCT/KR2016/011051
Publication Date:
April 27, 2017
Filing Date:
October 04, 2016
Export Citation:
Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
C12M3/00; C12N5/0793; C23C16/00
Foreign References:
| KR20140001010A | 2014-01-06 | |||
| KR20140097678A | 2014-08-07 |
Other References:
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ZHOU, ZHAOLI ET AL.: "The Role of Hydrogels with Tethered Acetylcholine Functionality on the Adhesion and Viability of Hippocampal Neurons and Glial Cells", BIOMATERISLS, vol. 33, no. 8, pages 2473 - 2481, XP028443483, [retrieved on 20111222]
PARK, SE WOONG ET AL.: "Generation of Functionalized Polymer Nanolayer on Implant Surface via Initiated Chemical Vapor Deposition (iCVD", JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 439, pages 34 - 41, XP055383270, [retrieved on 20141019]
MARI-BUYE, NURIA ET AL.: "FunctionaUzed, Swellable Hydrogel Layers as a Platform for Cell Studies", ADVANCED FUNCTIONAL MATERIALS, vol. 19, 2009, pages 1276 - 1286, XP055112531
PARK, HYUN-JI ET AL.: "Paper-based Bioactive Scaffolds for Stem Cell -mediated Bone Tissue Engineering", BIOMATERIALS, vol. 35, no. 37, pages 9811 - 9823, XP029070199, [retrieved on 20140917]
BAEK, JI EUNG ET AL.: "Oral Presentations of Graduate Students 109-15: ''A Vapor-phase Deposited Polymer Coating for Long-term Culture of Primary Neuron Cells", 2015 THE AUTUMN MEETING OF THE POLYMER SOCIETY OF KOREA, 6 October 2015 (2015-10-06)
BEAK, JIEUNG ET AL.: "Vapor-phase Deposited Biomimetic Polymer Surface for Stable Primary Neuron Culture", 2015 FALL CONFERENCE OF THE KOREAN SOCIETY FOR BIOMATERIALS, 22 October 2015 (2015-10-22)
TU, QIN ET AL.: "The Effect of Acetylcholine-like Biomimetic Polymers on Neuronal Growth", BIOMATERIALS , (ELECTRONIC PUBLISHING, vol. 32, no. 12, 6 February 2011 (2011-02-06), pages 3253 - 3264, XP028149168
ZHOU, ZHAOLI ET AL.: "The Role of Hydrogels with Tethered Acetylcholine Functionality on the Adhesion and Viability of Hippocampal Neurons and Glial Cells", BIOMATERISLS, vol. 33, no. 8, pages 2473 - 2481, XP028443483, [retrieved on 20111222]
PARK, SE WOONG ET AL.: "Generation of Functionalized Polymer Nanolayer on Implant Surface via Initiated Chemical Vapor Deposition (iCVD", JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 439, pages 34 - 41, XP055383270, [retrieved on 20141019]
MARI-BUYE, NURIA ET AL.: "FunctionaUzed, Swellable Hydrogel Layers as a Platform for Cell Studies", ADVANCED FUNCTIONAL MATERIALS, vol. 19, 2009, pages 1276 - 1286, XP055112531
PARK, HYUN-JI ET AL.: "Paper-based Bioactive Scaffolds for Stem Cell -mediated Bone Tissue Engineering", BIOMATERIALS, vol. 35, no. 37, pages 9811 - 9823, XP029070199, [retrieved on 20140917]
BAEK, JI EUNG ET AL.: "Oral Presentations of Graduate Students 109-15: ''A Vapor-phase Deposited Polymer Coating for Long-term Culture of Primary Neuron Cells", 2015 THE AUTUMN MEETING OF THE POLYMER SOCIETY OF KOREA, 6 October 2015 (2015-10-06)
BEAK, JIEUNG ET AL.: "Vapor-phase Deposited Biomimetic Polymer Surface for Stable Primary Neuron Culture", 2015 FALL CONFERENCE OF THE KOREAN SOCIETY FOR BIOMATERIALS, 22 October 2015 (2015-10-22)
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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