Title:
NERVE ELONGATION PROMOTER AND ELONGATION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2008/059959
Kind Code:
A1
Abstract:
It is intended to contribute to the elucidation of the mechanism of postzoster
neuralgia and to provide means for promoting the regeneration of damaged nerve.
Further, it is intended to provide means which is effective in the prevention
or treatment of a disorder caused by neuronal cell death accompanying postzoster
neuralgia, chronic pain, postherpetic neuralgia, apoplexy, a degenerative
disease or the like, or any of the above diseases, and has fewer side effects. A
neurite elongation promoter comprising an antibody that recognizes a varicella-zoster
virus immediate-early protein and crossreacts with a brain-derived neurotrophic
factor as an active ingredient; a preventive or therapeutic agent for a neurogenic
disease comprising the antibody as an active ingredient; a neurite elongation
inhibitor comprising an inhibitory antibody that recognizes a varicella-zoster
virus immediate-early protein and inhibits a brain-derived neurotrophic factor
as an active ingredient; and a preventive or therapeutic agent for a disease accompanied
by neural hypersensitivity caused by a condition selected from the group consisting
of postzoster neuralgia, chronic pain, experience-dependent social aversion
and stress, comprising the inhibitory antibody as an active ingredient.
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Inventors:
SHIRAKI KIMIYASU (JP)
HAMA YUKA (JP)
YOSHIDA YOSHIHIRO (JP)
TSUDA MASAAKI (JP)
TSUMOTO TADAHARU (JP)
ENDO TOSHIRO (JP)
TAKAHASHI MICHIAKI (JP)
HAMA YUKA (JP)
YOSHIDA YOSHIHIRO (JP)
TSUDA MASAAKI (JP)
TSUMOTO TADAHARU (JP)
ENDO TOSHIRO (JP)
TAKAHASHI MICHIAKI (JP)
Application Number:
PCT/JP2007/072284
Publication Date:
May 22, 2008
Filing Date:
November 16, 2007
Export Citation:
Assignee:
UNIV OSAKA RES FOUND (JP)
RIKEN (JP)
SHIRAKI KIMIYASU (JP)
HAMA YUKA (JP)
YOSHIDA YOSHIHIRO (JP)
TSUDA MASAAKI (JP)
TSUMOTO TADAHARU (JP)
ENDO TOSHIRO (JP)
TAKAHASHI MICHIAKI (JP)
RIKEN (JP)
SHIRAKI KIMIYASU (JP)
HAMA YUKA (JP)
YOSHIDA YOSHIHIRO (JP)
TSUDA MASAAKI (JP)
TSUMOTO TADAHARU (JP)
ENDO TOSHIRO (JP)
TAKAHASHI MICHIAKI (JP)
International Classes:
A61K39/395; A61P21/04; A61P25/00; A61P25/04; A61P25/16; A61P25/28; A61P25/30; A61P35/00; C07K16/08
Domestic Patent References:
| WO1994025585A1 | 1994-11-10 |
Foreign References:
| JP2002512627A | 2002-04-23 | |||
| JPH05328974A | 1993-12-14 | |||
| JPH0373280B2 | 1991-11-21 | |||
| JPH04506458A | 1992-11-12 | |||
| JPS62296890A | 1987-12-24 | |||
| JPH04504365A | 1992-08-06 | |||
| JPH06500233A | 1994-01-13 | |||
| JP2005185281A | 2005-07-14 | |||
| JPS5341202B2 | 1978-11-01 | |||
| US3985615A | 1976-10-12 |
Other References:
HAMA Y.: "Suiho Obi-jo Hosshin Virus (VZV) no Zen Shoki Tanpaku IE62 to Shinkei Inshi tono Kanren ni tsuite", CLINICAL VIROLOGY, vol. 35, no. 2, 21 May 2007 (2007-05-21), pages S94, XP003025828
LOWRY P.W. ET AL.: "Immunity in strain 2 guinea-pigs inoculated with vaccinia virus recombinants expressing varicella-zoster virus glycoproteins I, IV, V or the protein product of the immediate early gene 62", J. GENE VIROL., vol. 73, no. PART 4, 1992, pages 811 - 819, XP001056690
HUANG L. ET AL.: "Glial cell line-derived neurotrophic factor (GDNF) is required for differentiation of pontine noradrenergic neurons and patterning of central respiratory output", NEUROSCIENCE, vol. 130, no. 1, 2005, pages 95 - 105, XP025366611
KIMPINSKI K. ET AL.: "The anti-p75 antibody, MC192, and brain-derived neurotrophic factor inhibit nerve growth factor-dependent neurite growth from adult sensory neurons", NEUROSCIENCE, vol. 93, no. 1, 1999, pages 253 - 263, XP008109933
NAGAPPAN G. LU B., TRENDS IN NEUROSCIENCES, vol. 28, 2005, pages 464 - 471
BRAMHAM CR ET AL., PROGRESS IN NEUROLOGY, vol. 76, 2005, pages 99 - 125
COULL, J. A. M. ET AL., NATURE, vol. 438, 2005, pages 1017 - 1021
JOHNSON, R. W. ET AL., BMJ, vol. 326, 2003, pages 748 - 750
DONALD H.; GILDEN ET AL., NEUROLOGY, vol. 64, 2005, pages 21 - 25
J. GEN VIROL., vol. 67, 1986, pages 1759 - 1816
EXP. OPIN. THER. PATENTS, vol. 6, no. 5, 1996, pages 441 - 456
MILSTEIN ET AL., NATURE, vol. 256, 1975, pages 495 - 497
IKKEN IGAKU (EXTRA ISSUE), vol. 6, no. 10, 1988
NATURE GENETICS, vol. 15, 1997, pages 146 - 156
NATURE GENETICS, vol. 7, 1994, pages 13 - 21
NIKKEI, SCIENCE, 1995, pages 40 - 50
NATURE, vol. 368, 1994, pages 856 - 859
METH. ENZYMOL., vol. 92, 1983, pages 147 - 523
"Antibodies", vol. II, 1989, IRL PRESS OXFORD
JOURNAL OF VIROLOGY, November 2002 (2002-11-01), pages 11447 - 11459
TABUCHI, A. ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 35920 - 35931
KAWASAKI, E. S. ET AL.: "PCR Protocol, A Guide to methods and applications", 1991, ACADEMIC PRESS, INC., article "Amplification of RNA", pages: 21 - 27
OKUNO ET AL., VIROLOGY, vol. 129, 1983, pages 357 - 368
KIMURA ET AL., J NEUROPHYSIOL., vol. 77, no. 5, 1997, pages 2805 - 2815
IMAMURA L. ET AL., J PHARMACOL., EXP. THER, vol. 316, 2006, pages 136 - 143
See also references of EP 2095826A4
LOWRY P.W. ET AL.: "Immunity in strain 2 guinea-pigs inoculated with vaccinia virus recombinants expressing varicella-zoster virus glycoproteins I, IV, V or the protein product of the immediate early gene 62", J. GENE VIROL., vol. 73, no. PART 4, 1992, pages 811 - 819, XP001056690
HUANG L. ET AL.: "Glial cell line-derived neurotrophic factor (GDNF) is required for differentiation of pontine noradrenergic neurons and patterning of central respiratory output", NEUROSCIENCE, vol. 130, no. 1, 2005, pages 95 - 105, XP025366611
KIMPINSKI K. ET AL.: "The anti-p75 antibody, MC192, and brain-derived neurotrophic factor inhibit nerve growth factor-dependent neurite growth from adult sensory neurons", NEUROSCIENCE, vol. 93, no. 1, 1999, pages 253 - 263, XP008109933
NAGAPPAN G. LU B., TRENDS IN NEUROSCIENCES, vol. 28, 2005, pages 464 - 471
BRAMHAM CR ET AL., PROGRESS IN NEUROLOGY, vol. 76, 2005, pages 99 - 125
COULL, J. A. M. ET AL., NATURE, vol. 438, 2005, pages 1017 - 1021
JOHNSON, R. W. ET AL., BMJ, vol. 326, 2003, pages 748 - 750
DONALD H.; GILDEN ET AL., NEUROLOGY, vol. 64, 2005, pages 21 - 25
J. GEN VIROL., vol. 67, 1986, pages 1759 - 1816
EXP. OPIN. THER. PATENTS, vol. 6, no. 5, 1996, pages 441 - 456
MILSTEIN ET AL., NATURE, vol. 256, 1975, pages 495 - 497
IKKEN IGAKU (EXTRA ISSUE), vol. 6, no. 10, 1988
NATURE GENETICS, vol. 15, 1997, pages 146 - 156
NATURE GENETICS, vol. 7, 1994, pages 13 - 21
NIKKEI, SCIENCE, 1995, pages 40 - 50
NATURE, vol. 368, 1994, pages 856 - 859
METH. ENZYMOL., vol. 92, 1983, pages 147 - 523
"Antibodies", vol. II, 1989, IRL PRESS OXFORD
JOURNAL OF VIROLOGY, November 2002 (2002-11-01), pages 11447 - 11459
TABUCHI, A. ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 35920 - 35931
KAWASAKI, E. S. ET AL.: "PCR Protocol, A Guide to methods and applications", 1991, ACADEMIC PRESS, INC., article "Amplification of RNA", pages: 21 - 27
OKUNO ET AL., VIROLOGY, vol. 129, 1983, pages 357 - 368
KIMURA ET AL., J NEUROPHYSIOL., vol. 77, no. 5, 1997, pages 2805 - 2815
IMAMURA L. ET AL., J PHARMACOL., EXP. THER, vol. 316, 2006, pages 136 - 143
See also references of EP 2095826A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (1-1 Fushimimachi 4-chome, Chuo-ku, Osaka-sh, Osaka 44, JP)
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