Title:
NERVE FIBER DEGENERATION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2008/029871
Kind Code:
A1
Abstract:
It was verified that by an experiment using a gene-silencing nucleic acid (GalNAcST siRNA), which is a substance having an “action of inhibiting the synthesis” of chondroitin sulfate proteoglycan (CSPG), chondroitinase ABC, which is a substance having an “action of promoting the degradation” of CSPG and C4-sulfatase, which is a substance having an “action of desulfating” CSPG, a substance that “inhibits the production or accumulation of CSPG” in a totally different route of a totally different property has an effect of inhibiting nerve fiber degeneration. It was revealed that the substance that “inhibits the production or accumulation of CSPG” which is a feature common to these is useful for inhibiting nerve fiber degeneration. The invention relates to a nerve fiber degeneration inhibitor containing a substance that inhibits the production or accumulation of CSPG as an active ingredient and a screening method for the nerve fiber degeneration inhibitor.
Inventors:
YONEYAMA, Hiroyuki (STELIC INSTITUTE & CO. 9-15, Higashiazabu 1-chome, Minato-k, Tokyo 44, 1060044, JP)
米山 博之 (〒44 東京都港区東麻布１丁目９番１５号 株式会社ステリック再生医科学研究所内 Tokyo, 1060044, JP)
ISHIDA, Kenji (STELIC INSTITUTE & CO. 9-15, Higashiazabu 1-chome, Minato-k, Tokyo 44, 1060044, JP)
米山 博之 (〒44 東京都港区東麻布１丁目９番１５号 株式会社ステリック再生医科学研究所内 Tokyo, 1060044, JP)
ISHIDA, Kenji (STELIC INSTITUTE & CO. 9-15, Higashiazabu 1-chome, Minato-k, Tokyo 44, 1060044, JP)
Application Number:
JP2007/067375
Publication Date:
March 13, 2008
Filing Date:
September 06, 2007
Export Citation:
Assignee:
STELIC INSTITUTE OF REGENERATIVE MEDICINE, STELIC INSTITUTE & CO. (9-15, Higashiazabu 1-chome Minato-k, Tokyo 44, 1060044, JP)
株式会社ステリック再生医科学研究所 (〒44 東京都港区東麻布１丁目９番１５号 Tokyo, 1060044, JP)
YONEYAMA, Hiroyuki (STELIC INSTITUTE & CO. 9-15, Higashiazabu 1-chome, Minato-k, Tokyo 44, 1060044, JP)
米山 博之 (〒44 東京都港区東麻布１丁目９番１５号 株式会社ステリック再生医科学研究所内 Tokyo, 1060044, JP)
株式会社ステリック再生医科学研究所 (〒44 東京都港区東麻布１丁目９番１５号 Tokyo, 1060044, JP)
YONEYAMA, Hiroyuki (STELIC INSTITUTE & CO. 9-15, Higashiazabu 1-chome, Minato-k, Tokyo 44, 1060044, JP)
米山 博之 (〒44 東京都港区東麻布１丁目９番１５号 株式会社ステリック再生医科学研究所内 Tokyo, 1060044, JP)
International Classes:
A61K45/00; A61K31/713; A61K38/44; A61K48/00; A61P25/02; A61P25/28; A61P43/00; G01N33/15; G01N33/50; A61K45/00; A61K31/713; A61K38/43; A61K48/00; A61P25/00; A61P43/00; G01N33/15; G01N33/50
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (Kantetsu Tsukuba Bldg. 6F, 1-1-1 Oroshi-machi, Tsuchiura-sh, Ibaraki 47, 3000847, JP)