Title:
NERVE REPAIR PROTEIN COMPOSITION AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/143522
Kind Code:
A1
Abstract:
The present invention relates to a nerve repair protein composition. The preparation thereof comprises the following steps: adding 20 U/mL-35 U/mL of any one or a combination of nuclease or totipotent nuclease to a cell protein extract, placing at 37°C±1°C for enzymolysis for 15 min-40 min, and separating and purifying the prepared enzymatic liquid, so as to obtain the composition. The nerve repair protein composition of the present invention has the effects of cell repair and nerve damage repair, can be used for repairing nerve injury caused by diseases such as central nervous system injury, neurodegenerative disease, stroke, traumatic brain injury, ataxia, cerebral hemorrhage, Alzheimer's disease, Parkinson's disease, and senile dementia, or complications thereof, and has advantages of good stability, high bioavailability, safety and effectiveness, and convenient production, storage, and transportation.
Inventors:
WANG YU (CN)
GAO WENYONG (CN)
CHEN LIN (CN)
LI JIANJUN (CN)
GAO WENYONG (CN)
CHEN LIN (CN)
LI JIANJUN (CN)
Application Number:
PCT/CN2023/073582
Publication Date:
August 03, 2023
Filing Date:
January 28, 2023
Export Citation:
Assignee:
BEIJING DARWIN BIOTECH CO LTD (CN)
International Classes:
C07K1/14; A61K35/28; A61P9/10; A61P25/00; A61P25/28
Foreign References:
| US20150209390A1 | 2015-07-30 | |||
| CN113462673A | 2021-10-01 | |||
| CN111233972A | 2020-06-05 | |||
| US20190201477A1 | 2019-07-04 |
Other References:
SOMBATSRI AONNICHA; THUMMANANT YUTTHAPONG; SRIBUHOM THURDPONG; BOONMAK JAURSUP; YOUNGME SUJITTRA; PHUSRISOM SUPHANTHIP; KUKONGVIRI: "New limonophyllines A-C from the stem ofAtalantia monophyllaand cytotoxicity against cholangiocarcinoma and HepG2 cell lines", ARCHIVES OF PHARMACAL RESEARCH, NATL. FISHERIES UNIVERSITY , PUSAN, KR, vol. 41, no. 4, 15 March 2018 (2018-03-15), KR , pages 431 - 437, XP036488625, ISSN: 0253-6269, DOI: 10.1007/s12272-018-1021-7
Attorney, Agent or Firm:
BEIJING ZHIDA TONGCHENG INTELLECTUAL PROPERTY AGENCY (CN)
Download PDF: