Title:
NETWORKED CATIONIC POLYMER AND PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/090783
Kind Code:
A1
Abstract:
Provided are a networked cationic polymer and preparation thereof. Said networked cationic polymer has a backbone that involves aromatically conjugated imine linkages and possesses sufficient network cavity to load nucleic acids intra-molecularly. Said networked cationic polymer can be synthesized by reacting a linear or branched multi-amine bearing molecule or oligomer with an aromatic dialdehyde through Shiff-base reaction, and dropping the corresponding product to an aqueous solution of un-treated linear or branched multi-amine bearing molecule or oligomer under pre-determined pH. Said networked cationic polymer may be used to pack or absorb nucleic acids to form a uni-molecular polyplex. Said uni-molecular polyplex may be encapsulated by assembling a tri-block copolymer membrane on surface.
Inventors:
JIN TUO (CN)
CHEN SHUN (CN)
FENG JIA (CN)
CHEN SHUN (CN)
FENG JIA (CN)
Application Number:
PCT/CN2017/110731
Publication Date:
May 16, 2019
Filing Date:
November 13, 2017
Export Citation:
Assignee:
UNIV SHANGHAI JIAOTONG (CN)
International Classes:
C08G73/02; A61K9/48; A61K47/34; A61K48/00; C08G73/06; C12N11/08; C12N15/63; C12N15/88
Foreign References:
| CN103328542A | 2013-09-25 | |||
| CN103243122A | 2013-08-14 |
Other References:
CHEN S. ET AL.: "Functionally-tailorable Synthetic Carrier of Nucleic Acids Formed from Single Molecule of Cationic Polymer through Rational Assembly", 2016 CRS ANNUAL MEETING PRESENTATIONS, 20 July 2016 (2016-07-20)
Attorney, Agent or Firm:
BEIJING LONGAN LAW FIRM (CN)
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