Title:
A NEURAL CONDUIT TO RECONSTITUTE AND REGENERATE THE DEGENERATED OR DAMAGED NERVOUS SYSTEM
Document Type and Number:
WIPO Patent Application WO/2019/021320
Kind Code:
A3
Abstract:
A neural conduit to reconstitute and regenerate the degenerated or damaged nervous system comprising of acellularized meningeal scaffold repopulated with functional neuronal cells. The said neural conduit can be used as a biological implant in neurological conditions for filling the tissue gaps and in spinal cord injuries. A method for producing the neural conduit, comprising of repopulating the acellularized meningeal scaffold with regenerative cells to produce a large number of functional neuronal cells to augment the damaged/dysfunctional neural circuits
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Inventors:
VISHWAKARMA SANDEEP KUMAR (IN)
KHAN ALEEM AHMED (IN)
BARDIA AVINASH (IN)
PASPALA SYED AMEER BASHA (IN)
HABEEB MD AEJAZ (IN)
KHAN ALEEM AHMED (IN)
BARDIA AVINASH (IN)
PASPALA SYED AMEER BASHA (IN)
HABEEB MD AEJAZ (IN)
Application Number:
PCT/IN2018/050496
Publication Date:
September 12, 2019
Filing Date:
July 27, 2018
Export Citation:
Assignee:
DR HABEEBULLAH LIFE SCIENCES LTD (IN)
International Classes:
A61K35/30; A01N63/00; A61F13/00; A61K9/14; C12N5/02; C12N5/071; C12P21/04
Foreign References:
| US20160030635A1 | 2016-02-04 | |||
| US20140356331A1 | 2014-12-04 |
Other References:
DEQUACH ET AL.: "Decellularized Porcine Brain Matrix for Cell Culture and Tissue Engineering Scaffolds", TISSUE ENG PART A, vol. 17, no. 21-22, 2011, pages 2583 - 92, XP055489119, DOI: 10.1089/ten.tea.2010.0724
GATTAZZO ET AL.: "Extracellular matrix: A dynamic microenvironment for stem cell niche", BIOCHIMICA ET BIOPHYSICA ACTA (BBA), vol. 1840, no. 8, 2014, pages 2506 - 19, XP028872916, DOI: 10.1016/j.bbagen.2014.01.010
ASSUNCAO-SILVA ET AL.: "Hydrogels and Cell Based Therapies in Spinal Cord Injury Regeneration", STEM CELLS INTERNATIONAL, vol. 2015, 2015, pages 948040, XP055637474
CRAPO ET AL.: "Biologic scaffolds composed of central nervous system extracellular matrix", BIOMATERIALS, vol. 33, no. 13, 2012, pages 3539 - 3547, XP028461957, DOI: 10.1016/j.biomaterials.2012.01.044
PUTNAM: "The Instructive Role of the Vasculature in Stem Cell Niches", BIOMATERIAL SCIENCE, vol. 2, no. 11, 2014, pages 1562 - 1573, XP055637501
SHRESTHA ET AL.: "Repair of injured spinal cord using biomaterial scaffolds and stem cells", STEM CELL RESEARCH & THERAPY, vol. 5, no. 4, 2014, pages 91, XP021208906, DOI: 10.1186/scrt480
VISHWAKARMA ET AL.: "Bioengineering Human Neurological Constructs Using Decellularized Meningeal Scaffolds for Application in Spinal Cord Injury", FRONT BIOENG BIOTECHNOL, vol. 6, 1 November 2018 (2018-11-01), pages 150, XP055637503
GATTAZZO ET AL.: "Extracellular matrix: A dynamic microenvironment for stem cell niche", BIOCHIMICA ET BIOPHYSICA ACTA (BBA), vol. 1840, no. 8, 2014, pages 2506 - 19, XP028872916, DOI: 10.1016/j.bbagen.2014.01.010
ASSUNCAO-SILVA ET AL.: "Hydrogels and Cell Based Therapies in Spinal Cord Injury Regeneration", STEM CELLS INTERNATIONAL, vol. 2015, 2015, pages 948040, XP055637474
CRAPO ET AL.: "Biologic scaffolds composed of central nervous system extracellular matrix", BIOMATERIALS, vol. 33, no. 13, 2012, pages 3539 - 3547, XP028461957, DOI: 10.1016/j.biomaterials.2012.01.044
PUTNAM: "The Instructive Role of the Vasculature in Stem Cell Niches", BIOMATERIAL SCIENCE, vol. 2, no. 11, 2014, pages 1562 - 1573, XP055637501
SHRESTHA ET AL.: "Repair of injured spinal cord using biomaterial scaffolds and stem cells", STEM CELL RESEARCH & THERAPY, vol. 5, no. 4, 2014, pages 91, XP021208906, DOI: 10.1186/scrt480
VISHWAKARMA ET AL.: "Bioengineering Human Neurological Constructs Using Decellularized Meningeal Scaffolds for Application in Spinal Cord Injury", FRONT BIOENG BIOTECHNOL, vol. 6, 1 November 2018 (2018-11-01), pages 150, XP055637503
Attorney, Agent or Firm:
BHUPATHIRAJU, VSSRK Raju (IN)
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