Title:
NEURAL REGENERATION
Document Type and Number:
WIPO Patent Application WO/2011/022462
Kind Code:
A3
Abstract:
A method of promoting neural cell regeneration is carried out by contacting a neural cell with a compound that inhibits the binding of a chondroitin sulfate proteoglycan (CSPG ) to a cellular (e.g., transmembrane) PTPσ protein. The neural cell is associated with an injury or neurodegenerative condition.
Inventors:
FLANAGAN JOHN G (US)
TENNEY ALAN PETER (US)
SHEN YINGJIE (US)
TENNEY ALAN PETER (US)
SHEN YINGJIE (US)
Application Number:
PCT/US2010/045859
Publication Date:
June 16, 2011
Filing Date:
August 18, 2010
Export Citation:
Assignee:
HARVARD COLLEGE (US)
FLANAGAN JOHN G (US)
TENNEY ALAN PETER (US)
SHEN YINGJIE (US)
FLANAGAN JOHN G (US)
TENNEY ALAN PETER (US)
SHEN YINGJIE (US)
International Classes:
A61K39/395; A61K38/16; A61P25/00; A61P25/28
Foreign References:
| US20070010484A1 | 2007-01-11 |
Other References:
ARICESCU, A. R. ET AL.: "Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma.", MOL. CELL BIOL., vol. 22, no. 6, March 2002 (2002-03-01), pages 1881 - 1892, XP008014788, DOI: doi:10.1128/MCB.22.6.1881-1892.2002
DOBBERTIN, A. ET AL.: "Regulation of RPTPbeta/phosphacan expression and glycosaminoglycan epitopes in injured brain and cytokine-treated glia.", MOL. CELL NEUROSCI., vol. 24, no. 4, December 2003 (2003-12-01), pages 951 - 971
JONES, L. L. ET AL.: "The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury.", EXP. NEUROL., vol. 182, no. 2, August 2003 (2003-08-01), pages 399 - 411
SAPIEHA, P. S. ET AL.: "Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS.", MOL. CELL NEUROSCI., vol. 28, no. 4, April 2005 (2005-04-01), pages 625 - 635, XP004801862, DOI: doi:10.1016/j.mcn.2004.10.011
THOMPSON, K. M. ET AL.: "Receptor protein tyrosine phosphatase sigma inhibits axonal regeneration and the rate of axon extension.", MOL. CELL NEUROSCI., vol. 23, no. 4, August 2003 (2003-08-01), pages 681 - 692
FRY, E. J. ET AL.: "Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient mice.", GLIA., vol. 58, no. 4, March 2010 (2010-03-01), pages 423 - 433
DUAN, Y. ET AL.: "A new role for RPTPsigma in spinal cord injury: signaling chondroitin sulfate proteoglycan inhibition.", SCI. SIGNAL., vol. 3, no. 110, 23 February 2010 (2010-02-23), pages PE6
SHEN, Y. ET AL.: "PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration.", SCIENCE., vol. 326, no. 5952, 15 October 2009 (2009-10-15), pages 592 - 596, XP055123975, DOI: doi:10.1126/science.1178310
DOBBERTIN, A. ET AL.: "Regulation of RPTPbeta/phosphacan expression and glycosaminoglycan epitopes in injured brain and cytokine-treated glia.", MOL. CELL NEUROSCI., vol. 24, no. 4, December 2003 (2003-12-01), pages 951 - 971
JONES, L. L. ET AL.: "The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury.", EXP. NEUROL., vol. 182, no. 2, August 2003 (2003-08-01), pages 399 - 411
SAPIEHA, P. S. ET AL.: "Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS.", MOL. CELL NEUROSCI., vol. 28, no. 4, April 2005 (2005-04-01), pages 625 - 635, XP004801862, DOI: doi:10.1016/j.mcn.2004.10.011
THOMPSON, K. M. ET AL.: "Receptor protein tyrosine phosphatase sigma inhibits axonal regeneration and the rate of axon extension.", MOL. CELL NEUROSCI., vol. 23, no. 4, August 2003 (2003-08-01), pages 681 - 692
FRY, E. J. ET AL.: "Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient mice.", GLIA., vol. 58, no. 4, March 2010 (2010-03-01), pages 423 - 433
DUAN, Y. ET AL.: "A new role for RPTPsigma in spinal cord injury: signaling chondroitin sulfate proteoglycan inhibition.", SCI. SIGNAL., vol. 3, no. 110, 23 February 2010 (2010-02-23), pages PE6
SHEN, Y. ET AL.: "PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration.", SCIENCE., vol. 326, no. 5952, 15 October 2009 (2009-10-15), pages 592 - 596, XP055123975, DOI: doi:10.1126/science.1178310
Attorney, Agent or Firm:
RESNICK, David S. et al. (100 Summer StreetBoston, MA, US)
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