NEURAL STEM CELL AGENT FOR TREATMENT OF PARKINSON'S DISEASE BY INTRANASAL ADMINISTRATION, PREPARATION METHOD AND APPLICATION THEREOF

WIPO Patent Application WO/2018/149127

A1

The disclosure belongs to the biomedical technical field, and in particular relates to a neural stem cell agent for the treatment of Parkinson's disease by intranasal administration, and a preparation method and application thereof. The disclosure provides a preparation method of a neural stem cell agent for treatment of Parkinson's disease by intranasal administration, comprising the steps of: culturing and purifying a seed cell; culturing the cell to generation P6-P8; operating a cell bank; and formulating a therapeutic agent for Parkinson's disease. The disclosure provides a neural stem cell agent for the treatment of Parkinson's disease by intranasal administration, and a preparation method and application thereof. The agent quickly forms a solid film at body temperatures after being dropped or injected into the nasal cavity, attaches to the nasal cavity to be slowly absorbed by the cells, and does not enter into the oral cavity or the lungs with respiration, thereby facilitating use by the patient and the doctor, and experimental data shows that its efficacy and safety are better than dosing from the traumatic striatum. The agent can be used to treat Parkinson's disease and does not require the use of immunosuppressive agents.

ZHAO XIONGFEI (CN)
ZHENG JIAWEI (CN)
HUANG QIANYING (CN)

PCT/CN2017/101993

August 23, 2018

September 18, 2017

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SHANGHAI ANGECON BIOTECHNOLOGY CO LTD (CN)

A61K35/30; A61K9/00; A61P25/16; C12N5/0797

WO2004007700A1

2004-01-22

CN106924286A	2017-07-07
CN1966080A	2007-05-23
CN103271943A	2013-09-04
CN104928246A	2015-09-23
CN104031882A	2014-09-10

BEIJING GAOWO LAW FIRM (CN)

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