Title:
NEURALIZED PROTEIN, POLYNUCLEOTIDE ENCODING THE SAME, AND ANTIBODY RECOGNIZING THE SAME
Document Type and Number:
WIPO Patent Application WO/1999/025827
Kind Code:
A1
Abstract:
A gene causative of nerve mutation located in a site in the human tenth chromosome frequently suffering from deletion and having been identified; a protein (a nerve mutation factor) encoded by this gene; and an antibody against this protein. Because of showing a high homology with a $i(Drosophila) neuralized gene, this human gene causative of nerve mutation is a human homolog of the neuralized gene. Also, provision is made of a mouse neuralized gene; a protein encoded by this gene; and an antibody against the same.
Inventors:
NAKATA MOTOMI (JP)
NAKAMURA HIDEO (JP)
YOSHIDA MITSUHIRO (JP)
SAYA HIDEYUKI (JP)
NAKAMURA HIDEO (JP)
YOSHIDA MITSUHIRO (JP)
SAYA HIDEYUKI (JP)
Application Number:
PCT/JP1998/003737
Publication Date:
May 27, 1999
Filing Date:
August 24, 1998
Export Citation:
Assignee:
SUMITOMO ELECTRIC INDUSTRIES (JP)
NAKATA MOTOMI (JP)
NAKAMURA HIDEO (JP)
YOSHIDA MITSUHIRO (JP)
SAYA HIDEYUKI (JP)
NAKATA MOTOMI (JP)
NAKAMURA HIDEO (JP)
YOSHIDA MITSUHIRO (JP)
SAYA HIDEYUKI (JP)
International Classes:
G01N33/53; C07K14/47; C07K16/18; C12N15/00; C12N15/09; C12N15/12; C12P21/02; C12P21/08; C12Q1/68; C12R1/19; C12R1/91; (IPC1-7): C12N15/12; C07K14/47; C07K16/18; C12P21/08; C12Q1/68
Other References:
ONCOGENE, Vol. 16(8), 26 Feb. 1998, NAKAMURA H. et al., " Identification of a Human Homolog of the Drosophila Neuralized Gene within the 10q25.1 Malignant Astrocytoma Deletion Region", p. 1009-1019.
EMBL, Rel. 45, (1995), Accession No. R90763, HILLIER L. et al., "yn02d01.rl Homo sapiens cDNA clone 167233 5'".
EMBL, Rel. 45, (1995), Accession No. H82634, HILLIER L. et al., "ys70e12.rl Homo sapiens cDNA clone 220174 5'".
EMBL, Rel. 45, (1995), Accession No. H51467, HILLIER L. et al., "yo31e03.rl Homo sapiens cDNA clone 179548 5'".
EMBL, Rel. 48, (1996), Accession No. N89880, HILLIER L. et al., "zb35d12.sl Soares Parathyroid Tumor NbHPA Homo sapiens cDNA clone 305591 3'".
EMBO J., Vol. 10(10), (1991), BOULIANNE G.L. et al., "The Drosophila Neurogenic Gene Neuralized Encodes a Novel Protein and is Expression in Precursors of Larval and Adult Neurons", p. 2975-2983.
EMBO J., Vol. 12(6), (1993), BOULIANNE G.L. et al., "The Drosophila Neurogenic Gene Neuralized Encodes a Novel Protein and is Expression in Precursors of Larval and Adult Neurons", p. 2586.
EMBO J., Vol. 12(6), (1993), PRICE B.D. et al., "The Drosophila Neuralized Gene Encodes a C3HC4 Zinc Finger", p. 2411-2418.
EMBL, Rel. 45, (1995), Accession No. R90763, HILLIER L. et al., "yn02d01.rl Homo sapiens cDNA clone 167233 5'".
EMBL, Rel. 45, (1995), Accession No. H82634, HILLIER L. et al., "ys70e12.rl Homo sapiens cDNA clone 220174 5'".
EMBL, Rel. 45, (1995), Accession No. H51467, HILLIER L. et al., "yo31e03.rl Homo sapiens cDNA clone 179548 5'".
EMBL, Rel. 48, (1996), Accession No. N89880, HILLIER L. et al., "zb35d12.sl Soares Parathyroid Tumor NbHPA Homo sapiens cDNA clone 305591 3'".
EMBO J., Vol. 10(10), (1991), BOULIANNE G.L. et al., "The Drosophila Neurogenic Gene Neuralized Encodes a Novel Protein and is Expression in Precursors of Larval and Adult Neurons", p. 2975-2983.
EMBO J., Vol. 12(6), (1993), BOULIANNE G.L. et al., "The Drosophila Neurogenic Gene Neuralized Encodes a Novel Protein and is Expression in Precursors of Larval and Adult Neurons", p. 2586.
EMBO J., Vol. 12(6), (1993), PRICE B.D. et al., "The Drosophila Neuralized Gene Encodes a C3HC4 Zinc Finger", p. 2411-2418.
Attorney, Agent or Firm:
Hasegawa, Yoshiki (6th floor 13-10, Kyobashi 2-chome Chuo-ku Tokyo, JP)
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