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Title:
NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/010054
Kind Code:
A3
Abstract:
Described herein are neuroactive steroids of the Formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof; wherein R1a and R1b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

Inventors:
MARTINEZ BOTELLA, Gabriel (17 Parmenter Road, Wayland, MA, 01778, US)
HARRISON, Boyd L. (9 Wheatston Court, Princeton Junction, NJ, 08550, US)
ROBICHAUD, Albert, Jean (2 Earhart St, 915Cambridge, MA, 02141, US)
SALITURO, Francesco Gerald (25 Baker Drive, Marlborough, MA, 01752, US)
Application Number:
US2014/047246
Publication Date:
April 09, 2015
Filing Date:
July 18, 2014
Export Citation:
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Assignee:
SAGE THERAPEUTICS, INC. (215 First Street, Cambridge, MA, 02142, US)
International Classes:
A61K31/56; A61P25/00; C07J3/00
Domestic Patent References:
WO1994027608A11994-12-08
WO2012116290A22012-08-30
Other References:
See also references of EP 3021852A4
Attorney, Agent or Firm:
YEE, Dominic Jason (Lando & Anastasi LLP, Riverfront Office ParkOne Main Street, Suite 110, Cambridge MA, 02142, US)
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