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Title:
NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/180679
Kind Code:
A1
Abstract:
Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I) : and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.

Inventors:
BOTELLA, Gabriel Martinez (17 Parmenter Road, Wayland, Massachusetts, 01778, US)
HARRISON, Boyd L. (9 Wheatston Court, Princeton Junction, New Jersey, 08550, US)
ROBICHAUD, Albert Jean (215 First Street, Cambridge, Massachusetts, 02142, US)
SALITURO, Francesco G. (25 Baker Drive, Marlborough, Massachusetts, 01752, US)
BERESIS, Richard Thomas (Apartment 2504, Building 1199 Shimen #2 Road, Shanghai 0, 200040, CN)
Application Number:
CN2015/080216
Publication Date:
December 03, 2015
Filing Date:
May 29, 2015
Export Citation:
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Assignee:
SAGE THERAPEUTICS, INC. (215 First Street, Cambridge, Massachusetts, 02142, US)
BOTELLA, Gabriel Martinez (17 Parmenter Road, Wayland, Massachusetts, 01778, US)
HARRISON, Boyd L. (9 Wheatston Court, Princeton Junction, New Jersey, 08550, US)
ROBICHAUD, Albert Jean (215 First Street, Cambridge, Massachusetts, 02142, US)
SALITURO, Francesco G. (25 Baker Drive, Marlborough, Massachusetts, 01752, US)
BERESIS, Richard Thomas (Apartment 2504, Building 1199 Shimen #2 Road, Shanghai 0, 200040, CN)
International Classes:
C07J5/00; A61K31/57; A61K31/58; A61P25/00; C07J7/00
Domestic Patent References:
WO2013056181A12013-04-18
Foreign References:
US5939545A1999-08-17
US5376645A1994-12-27
US5232917A1993-08-03
Other References:
GABRIEL MARTINEZ BOTELLA ET AL.: "NEUROACTIVE STEROIDS , 1. POSITIVE ALLOSTERIC MODULATORS OF THE (y-AMINOBUTYRIC ACID)A RECEPTRO: STRUCTURE-ACTIVITY RELATIONSHIPS OF HETEROCYCLIC SUBSTITUTION AT C-21", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 8, 23 March 2015 (2015-03-23), pages 3500 - 3511, XP055239491, ISSN: 0022-2623
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Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (10th Floor, Building 110 Caihefang Road,Haidian District, Beijing 1, 100101, CN)
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