Title:
NEURODEGENERATIVE DISEASE TESTING METHOD
Document Type and Number:
WIPO Patent Application WO/2015/060317
Kind Code:
A1
Abstract:
Provided is a neurodegenerative disease testing method which is not burdensome on the human or animal test subject, and which not only can determine whether said test subject suffers from neurodegenerative disease, but also whether there is a high risk thereof in the future. The homocysteic acid concentration in urine collected from the test subject, the homocysteic acid concentration in blood collected from the test subject and the homocysteine and/or methionine concentration in the same blood are measured. This testing method further is characterized by measuring the creatinine concentration in the urine and the creatinine concentration in the blood.
Inventors:
HASEGAWA TOHRU (JP)
Application Number:
PCT/JP2014/077999
Publication Date:
April 30, 2015
Filing Date:
October 21, 2014
Export Citation:
Assignee:
HASEGAWA TOHRU (JP)
M R D CO LTD (JP)
M R D CO LTD (JP)
International Classes:
G01N33/68; G01N33/70
Foreign References:
| JP2010077162A | 2010-04-08 | |||
| JP2005082523A | 2005-03-31 |
Other References:
HASEGAWA T ET AL.: "Urinary homocysteic acid levels correlate with mini-mental state examination scores in Alzheimer's disease patients", JOURNAL OF ALZHEIMER'S DISEASE, vol. 31, no. 1, 2012, pages 59 - 64
IKURO MARUYAMA: "Seikagakuteki Kensa [1] D. Teibunshi Chisso Kagobutsu Kankei Homocysteine", NIPPON RINSYO, vol. 62, no. SUPPL., 2004, pages 620 - 622
MCCAMPBELL ALEXANDER ET AL.: "Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine", J NEUROCHEM, vol. 116, no. 1, 2011, pages 82 - 92
ADAM DAVEY ET AL.: "Decline in renal functioning is associated with longitudinal decline in global cognitive functioning, abstract reasoning and verbal memory", NEPHROL DIAL TRANSPLANT, 2012, pages 1 - 8
FUKASHI UDAKA: "Chiho to Homocysteine: Alzheimer's Disease no Atarashii Kiken Inshi ka?", DEMENTIA JAPAN, vol. 14, 2000, pages 136 - 13 9
ZHUO JIA-MIN ET AL.: "Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?", TRENDS PHARMACOL SCI, vol. 32, no. 9, 2011, pages 562 - 571
IKURO MARUYAMA: "Seikagakuteki Kensa [1] D. Teibunshi Chisso Kagobutsu Kankei Homocysteine", NIPPON RINSYO, vol. 62, no. SUPPL., 2004, pages 620 - 622
MCCAMPBELL ALEXANDER ET AL.: "Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine", J NEUROCHEM, vol. 116, no. 1, 2011, pages 82 - 92
ADAM DAVEY ET AL.: "Decline in renal functioning is associated with longitudinal decline in global cognitive functioning, abstract reasoning and verbal memory", NEPHROL DIAL TRANSPLANT, 2012, pages 1 - 8
FUKASHI UDAKA: "Chiho to Homocysteine: Alzheimer's Disease no Atarashii Kiken Inshi ka?", DEMENTIA JAPAN, vol. 14, 2000, pages 136 - 13 9
ZHUO JIA-MIN ET AL.: "Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?", TRENDS PHARMACOL SCI, vol. 32, no. 9, 2011, pages 562 - 571
Attorney, Agent or Firm:
MATSUO KENICHIRO (JP)
Ken-ichiro Matsuo (JP)
Ken-ichiro Matsuo (JP)
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