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Patent Searching and Data


Title:
NEURON-PROTECTIVE COMPOSITION COMPRISING CASSIA OBTUSIFOLIA SHOOT-DERIVED NAPHTHOPYRONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2020/050462
Kind Code:
A1
Abstract:
The present invention relates to a naphthopyrone derivative and a composition comprising, as an active ingredient, a Cassia obtusifolia shoot extract including the naphthopyrone derivative. A composition according to an aspect of the present invention has an antioxidative effect and an effect of protecting neurons from oxidative stress or inhibiting the death of neurons, and in particular, has an effect of inhibiting damage or death of retinal neurons or hippocampal neurons due to glutamate toxicity, and thus the composition can be used as a pharmaceutical or food composition for the treatment or prevention of eye diseases and deterioration and loss of vision caused by optic nerve injury, and for the treatment or prevention memory loss, decline in learning ability, onset and worsening of depressive disorders, and degenerative neurological diseases caused by brain nerve damage.

Inventors:
KWON HAK CHEOL (KR)
PARK JIN SOO (KR)
KWON JAEYOUNG (KR)
HWANG HO SEONG (KR)
LEE JUNG HWAN (KR)
LEE JAE WOOK (KR)
KIM DONG HOI (KR)
KIM HYOUNG SEOK (KR)
CHANG SUNG YUL (KR)
JUNG SANG HOON (KR)
Application Number:
PCT/KR2019/000399
Publication Date:
March 12, 2020
Filing Date:
January 10, 2019
Export Citation:
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Assignee:
KOREA INST SCI & TECH (KR)
International Classes:
C07H15/26; A23L33/105; C07C49/643; C07D311/78; C07H1/08; C12N5/079
Foreign References:
US20080182803A12008-07-31
US20040044067A12004-03-04
Other References:
DONG, X. ET AL.: "Cassiae semen: A review of its phytochemistry and pharmacology (Review)", MOLECULAR MEDICINE REPORTS, vol. 16, 2017, pages 2331 - 2346, XP055693248
TANG, L. ET AL.: "Four new glycosides from the seeds of Cassia obtusifolia", PHYTOCHEMISTRY LETTERS, vol. 13, 2015, pages 81 - 84, XP055693249
SHRESTHA, S. ET AL.: "Structure Related Inhibition of Enzyme Systems in Choline sterases and BACE1 In Vitro by Naturally Occurring Naphthopyrone and Its Glycosides Isolated from Cassia obtusifolia", MOLECULES, vol. 23, 69, 28 December 2017 (2017-12-28), pages 1 - 17, XP055693252
Attorney, Agent or Firm:
KIM, Sun-young (KR)
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