Title:
NEUROPROTECTIVE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2011/163241
Kind Code:
A3
Abstract:
This disclosure relates to compounds that can be utilized to treat a neural injury or disorder. Methods of identifying and making these compounds are also set forth herein.
Inventors:
DJAKIEW DANIEL (US)
EL TOUNY LARA H (US)
EL TOUNY LARA H (US)
Application Number:
PCT/US2011/041265
Publication Date:
March 20, 2014
Filing Date:
June 21, 2011
Export Citation:
Assignee:
UNIV GEORGETOWN (US)
DJAKIEW DANIEL (US)
EL TOUNY LARA H (US)
DJAKIEW DANIEL (US)
EL TOUNY LARA H (US)
International Classes:
A01N43/90
Foreign References:
| US20060276393A1 | 2006-12-07 | |||
| US20080064036A1 | 2008-03-13 | |||
| US20050239882A1 | 2005-10-27 | |||
| US20030109027A1 | 2003-06-12 |
Other References:
CULMSEE ET AL.: "NERVE GROWTH FACTOR SURVIVAL SIGNALING IN CULTURED HIPPOCAMPAL NEURONS IS MEDIATED THROUGH TRKA AND REQUIRES THE COMMON NEUROTROPHIN RECEPTOR P75.", NEUROSCIENCE, vol. 115, no. 4, 2002, pages 1089 - 1108
QUANN ET AL.: "The p38 MAPK Pathway Mediates Aryl Propionic Acid.lnduced Messenger RNA Stability of p75NTR in Prostate Cancer Cells.", CANCER RES, vol. 67, 2007, pages 11402 - 11410
NGUYEN ET AL.: "The intracellular genistein metabolite 5,7,3-tetrahydroxyisoflavone mediates G2-M cell cycle arrest in cancer cells via modulation of the p38 signaling pathway.", FREE RADICAL BIOLOGY & MEDICINE, vol. 41, 2006, pages 1225 - 1239
MUNOZ ET AL.: "Targeting p38 MAPK pathway for the treatment of Alzheimer's disease.", NEUROPHARMACOLOGY, vol. 58, 2010, pages 561 - 568
SONEE ET AL.: "The Soy Isoflavone, Genistein, Protects Human Cortical Neuronal Cells from Oxidative Stress.", NEUROTOXICOLOGY, vol. 25, 2004, pages 885 - 891
SCHROETER ET AL.: "Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3.", BIOCHEM. J., vol. 358, 2001, pages 547 - 557
QUANN ET AL.: "The p38 MAPK Pathway Mediates Aryl Propionic Acid.lnduced Messenger RNA Stability of p75NTR in Prostate Cancer Cells.", CANCER RES, vol. 67, 2007, pages 11402 - 11410
NGUYEN ET AL.: "The intracellular genistein metabolite 5,7,3-tetrahydroxyisoflavone mediates G2-M cell cycle arrest in cancer cells via modulation of the p38 signaling pathway.", FREE RADICAL BIOLOGY & MEDICINE, vol. 41, 2006, pages 1225 - 1239
MUNOZ ET AL.: "Targeting p38 MAPK pathway for the treatment of Alzheimer's disease.", NEUROPHARMACOLOGY, vol. 58, 2010, pages 561 - 568
SONEE ET AL.: "The Soy Isoflavone, Genistein, Protects Human Cortical Neuronal Cells from Oxidative Stress.", NEUROTOXICOLOGY, vol. 25, 2004, pages 885 - 891
SCHROETER ET AL.: "Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3.", BIOCHEM. J., vol. 358, 2001, pages 547 - 557
Attorney, Agent or Firm:
MCKEON, Tina, Williams (Meunier Carlin & Curfman, LLC,Suite 900,817 W. Peachtree Street N, Atlanta Georgia, US)
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