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Document Type and Number:
WIPO Patent Application WO/2017/170924
Kind Code:
The purpose of the present invention is to provide a peptide which has a neuroprotective action, a neuroprotective drug and neuropathic treatment containing said peptide, and a preventive or alleviative pharmaceutical composition. This is based on the finding that a peptide fragment isolated from proline-rich protein 4 (PRP4) has a neuroprotective action.

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NAKAJIMA, Takeshi (2-5-8, Hirano-machi, Chuo-ku, Osaka-sh, Osaka 46, 〒5410046, JP)
MACHIDA, Mamiko (2-5-8, Hirano-machi, Chuo-ku, Osaka-sh, Osaka 46, 〒5410046, JP)
HAYASHI, Yujiro (4-3 Minatojimaminamimachi 6-Chome, Chuo-ku Kobe-sh, Hyogo 47, 〒6500047, JP)
Application Number:
Publication Date:
October 05, 2017
Filing Date:
March 30, 2017
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SENJU PHARMACEUTICAL CO.,LTD. (2-5-8, Hirano-machi Chuo-ku, Osaka-sh, Osaka 46, 〒5410046, JP)
International Classes:
C07K7/08; A61K38/00; A61P9/10; A61P21/02; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P27/16; C07K5/117; C07K7/06; C07K14/47
Foreign References:
Other References:
MARUYAMA S. ET AL.: "Aminopeptidase P, capable of hydrolyzing oligoproline, from Bovine Brain", BIOSCI. BIOTECH. BIOCHEM., vol. 58, no. 11, 1994, pages 2107 - 2108, XP055430144, ISSN: 0916-8451
YENKOYAN K. ET AL.: "Neuroprotective action of proline-rich polypeptide-1 in beta-amyloid induced neurodegeneration in rats", BRAIN RESEARCH BULLETIN, vol. 86, 2011, pages 262 - 271, XP028297900, ISSN: 0361-9230
GALOYAN A. A. ET AL.: "Protective effects of hypothalamic proline-rich peptide and cobra venom Naja Naja Oxiana on dynamics of vestibular compensation following unilateral labyrinthectomy", NEUROCHEM. RES ., vol. 35, 2010, pages 1747 - 1760, XP019827428, ISSN: 0364-3190
FUNG K-Y. C. ET AL.: "Characterization of the in vivo forms of lacrimal-specific proline rich proteins in human tear fluid", PROTEOMICS, vol. 4, 2004, pages 3953 - 3959, XP055430147, ISSN: 1615-9861
DATABASE Database UniProt [O] 27 May 2002 (2002-05-27), "Proline-rich protein 4", XP055430150, Database accession no. Q16378
Attorney, Agent or Firm:
AOKI, Atsushi et al. (SEIWA PATENT & LAW, Toranomon 37 Mori Bldg. 5-1, Toranomon 3-chome, Minato-k, Tokyo 23, 〒1058423, JP)
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