Title:
NEUROTROPHIC FACTOR PRODUCTION ACCELERATING APPARATUS
Document Type and Number:
WIPO Patent Application WO/2008/056414
Kind Code:
A1
Abstract:
In order to treat or prevent various diseases such as brain diseases, a neurotrophic
factor production accelerating apparatus for accelerating the production
of a neurotrophic factor or a neurotrophic factor-like substance in an affected
part by a simple method without cell transplantation or injection into the affected
part and regardless of the place for treatment is provided. For applying a high-frequency
alternating magnetic field in the range of 20 to 180 MHz, 280 to 600 MHz and 700 to
1000 MHz to a cell at a magnetic flux density of 0.01 T or less, the neurotrophic
factor production accelerating apparatus is provided with a high-frequency
electromagnetic wave generator for generating a high-frequency electromagnetic
wave with the above-mentioned frequency. By the magnetic stimulation from the
high-frequency alternating magnetic field with the above-mentioned high frequency,
an intracellular calcium ion concentration is increased and exocytosis of neurotrophic
factors is induced, and also a transcription factor (mRNA) of neurotrophic factors
in a cell is increased by magnetic stimulation thereby to accelerate the synthesis
of neurotrophic factors and the release thereof to the outside of the cell.
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Inventors:
NISHI MITSUHARU (JP)
KISHITA IWAO (JP)
KISHITA IWAO (JP)
Application Number:
PCT/JP2006/322295
Publication Date:
May 15, 2008
Filing Date:
November 08, 2006
Export Citation:
Assignee:
MEDICAL APPLIANCE CO LTD (JP)
NISHI MITSUHARU (JP)
KISHITA IWAO (JP)
NISHI MITSUHARU (JP)
KISHITA IWAO (JP)
International Classes:
A61N2/00
Domestic Patent References:
| WO1999001178A1 | 1999-01-14 | |||
| WO1997013549A1 | 1997-04-17 |
Foreign References:
| JP2006094940A | 2006-04-13 | |||
| JP2000504966A | 2000-04-25 | |||
| JP2004511314A | 2004-04-15 | |||
| US20060021077A1 | 2006-01-26 | |||
| US6425851B1 | 2002-07-30 | |||
| DE19752934A1 | 1998-12-03 | |||
| US20030028071A1 | 2003-02-06 |
Other References:
FUJIKI M.: "Magnetic stimulation of the Brain", THE MAGNETICS SOCIETY OF JAPAN KENKYUKAI SHIRYO, vol. 125TH, 2002, pages 3 - 10, XP003022544
FUNAMIZU H.: "Kohindo Jiki Shigeki no Nosaibo ni Oyobosu Eikyo (The effects of rTMS on rat brain cells)", THE INSTITUTE OF ELECTRICAL ENGINEERS OF JAPAN MAGNETICS KENKYUKAI SHIRYO, (MAG-02, 45-62.64-65), 2002, pages 17 - 20, XP003022545
OKADA T.: "ECT to TMS no Syo Kijo - Seikagakuteki Kenkyu kara -", JAPANESE JOURNAL OF CLINICAL PSYCHIATRY, vol. 32, no. 3, 2003, pages 245 - 251, XP003022546
See also references of EP 2081645A4
FUNAMIZU H.: "Kohindo Jiki Shigeki no Nosaibo ni Oyobosu Eikyo (The effects of rTMS on rat brain cells)", THE INSTITUTE OF ELECTRICAL ENGINEERS OF JAPAN MAGNETICS KENKYUKAI SHIRYO, (MAG-02, 45-62.64-65), 2002, pages 17 - 20, XP003022545
OKADA T.: "ECT to TMS no Syo Kijo - Seikagakuteki Kenkyu kara -", JAPANESE JOURNAL OF CLINICAL PSYCHIATRY, vol. 32, no. 3, 2003, pages 245 - 251, XP003022546
See also references of EP 2081645A4
Attorney, Agent or Firm:
KAMEYA, Yoshiaki (Daiichi Tomizawa Building3-1-3, Yotsuy, Shinjuku-ku Tokyo 04, JP)
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