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Title:
NEUTRALIZING HUMAN MONOCLONAL ANTIBODY 8D6 AGAINST HCV INFECTION
Document Type and Number:
WIPO Patent Application WO/2017/206621
Kind Code:
A1
Abstract:
Provided herein is a human monoclonal antibody 8D6 against hepatitis C virus (HCV) infection. The antibody binds to the E2 subunit of HCV capsid protein, and can prevent HCV from infecting susceptible host cells. By using the antibody variable region gene or the complementary determining region (CDR) gene, different forms of genetic engineering antibodies have been transformed and produced in any expression system of the prokaryotic and eukaryotic cells as therapeutics to prevent or treat HCV infection.

Inventors:
ZHOU, Honglin (4th Floor C19 Building, Biobay 218 Xinghu Street, SI, Suzhou Jiangsu 8, 215028, CN)
LIU, Jie (4th Floor C19 Building, Biobay 218 Xinghu Street, SI, Suzhou Jiangsu 8, 215028, CN)
DONG, Xin (4th Floor C19 Building, Biobay 218 Xinghu Street, SI, Suzhou Jiangsu 8, 215028, CN)
SUN, Bing (319 Yueyang Road, Shanghai 1, 200031, CN)
WANG, Jiangjun (319 Yueyang Road, Shanghai 1, 200031, CN)
LING, Zhiyang (319 Yueyang Road, Shanghai 1, 200031, CN)
YI, Chunyan (319 Yueyang Road, Shanghai 1, 200031, CN)
BIAN, Chao (319 Yueyang Road, Shanghai 1, 200031, CN)
Application Number:
CN2017/081533
Publication Date:
December 07, 2017
Filing Date:
April 21, 2017
Export Citation:
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Assignee:
SUZHOU GALAXY BIOPHARMA, CO., LTD. (4th Floor C19 Building, Biobay 218 Xinghu Street, SI, Suzhou Jiangsu 8, 215028, CN)
International Classes:
C07K16/10; A61K39/395; A61K39/42; A61P31/14; C12N15/13; C12N15/63; G01N33/577
Domestic Patent References:
WO2010039154A12010-04-08
WO2013033319A22013-03-07
WO2002008292A22002-01-31
WO2008108918A12008-09-12
Foreign References:
CN105330730A2016-02-17
CN105254756A2016-01-20
CN103642792A2014-03-19
Attorney, Agent or Firm:
BEIJING ARETE INTELLECTUAL PROPERTY AGENCY (Suite 1201, Building 3 Zhubang 2000 Business Center,No. 98, Ba Li Zhuang Xi Li, Chaoyang District, Beijing 5, 100025, CN)
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