Title:
NEW 2,3-BENZODIAZEPINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2001004122
Kind Code:
A3
Abstract:
The invention relates to new 2,3-benzodiazepine derivatives of general Formula (I), (wherein R<1> stands for methyl, formyl, carboxy, cyano, -CH=NOH, -CH=NNHCONH2 or -NR<5>R<6>, wherein R<5> and R<6> independently from each other represent hydrogen or lower alkyl or together with the nitrogen atom, they are attached to, form a 5- or 6-membered, saturated or unsaturated heterocyclic ring optionally containing one or more further nitrogen, sulfur and/or oxygen atom(s); R<2> is nitro or amino; R<3> stands for hydrogen, lower alkanoyl or CO-NR<7>R<8>, wherein R<7> and R<8> independently from each other stand for hydrogen, lower alkoxy, lower alkyl or lower cycloalkyl or together with the nitrogen atom, they are attached to, form a 5- or 6-membered, saturated or unsaturated heterocyclic ring optionally containing one or more further nitrogen, sulfur and/or oxygen atom(s); R<4> is hydrogen or lower alkyl; the dotted lines have the following meaning: if R<3> and R<4> are not present, the bond between positions C<8> and C<9> is a single bond and the bond between positions C<8> and N<7> is a double bond; if R<3> and R<4> are present, the bonds between positions C<8> and C<9> and between position C<8> and N<7> are single bonds; and if R<3> is present and R<4> is missing, the bond between positions C<8> and C<9> is a double bond and the bond between positions C<8> and N<7> is a single bond) and salts thereof. The invention compounds have neuroprotective effect.
Inventors:
GREFF ZOLTAN (HU)
SZABO GEZA (HU)
BARKOCZY JOZSEF (HU)
RATKAI ZOLTAN (HU)
BLASKO GABOR (HU)
SIMIG GYULA (HU)
GIGLER GABOR (HU)
MARTONNE MARKO BERNADETT (HU)
LEVAY GYOERGY (HU)
TIHANYI KAROLY (HU)
EGYED ANDRAS (HU)
SIMO ANNAMARIA (HU)
SZABO GEZA (HU)
BARKOCZY JOZSEF (HU)
RATKAI ZOLTAN (HU)
BLASKO GABOR (HU)
SIMIG GYULA (HU)
GIGLER GABOR (HU)
MARTONNE MARKO BERNADETT (HU)
LEVAY GYOERGY (HU)
TIHANYI KAROLY (HU)
EGYED ANDRAS (HU)
SIMO ANNAMARIA (HU)
Application Number:
PCT/HU2000/000074
Publication Date:
May 10, 2001
Filing Date:
July 04, 2000
Export Citation:
Assignee:
EGYT GYOGYSZERVEGYESZETI GYAR (HU)
GREFF ZOLTAN (HU)
SZABO GEZA (HU)
BARKOCZY JOZSEF (HU)
RATKAI ZOLTAN (HU)
BLASKO GABOR (HU)
SIMIG GYULA (HU)
GIGLER GABOR (HU)
MARTONNE MARKO BERNADETT (HU)
LEVAY GYOERGY (HU)
TIHANYI KAROLY (HU)
EGYED ANDRAS (HU)
SIMO ANNAMARIA (HU)
GREFF ZOLTAN (HU)
SZABO GEZA (HU)
BARKOCZY JOZSEF (HU)
RATKAI ZOLTAN (HU)
BLASKO GABOR (HU)
SIMIG GYULA (HU)
GIGLER GABOR (HU)
MARTONNE MARKO BERNADETT (HU)
LEVAY GYOERGY (HU)
TIHANYI KAROLY (HU)
EGYED ANDRAS (HU)
SIMO ANNAMARIA (HU)
International Classes:
A61K31/551; A61P1/08; A61P13/00; A61P21/00; A61P25/00; A61P25/04; C07D491/056; A61P25/06; A61P25/08; A61P25/16; A61P25/18; A61P25/22; A61P25/28; A61P25/30; C07D491/04; C07D243/00; C07D317/00; (IPC1-7): C07D491/04; A61K31/551; A61P25/00
Domestic Patent References:
| WO1999007707A1 | 1999-02-18 | |||
| WO1992011262A1 | 1992-07-09 | |||
| WO1997034878A1 | 1997-09-25 | |||
| WO1995001357A1 | 1995-01-12 |
Foreign References:
| EP0492485A1 | 1992-07-01 |
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