Title:
NEW ACYLGLYCEROL ACYLTRANSFERASE-LIKE PROTEINS DC4 AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2005075630
Kind Code:
A3
Abstract:
The present invention is directed to polynucleotide and polypeptide sequences of novel acylglycerol acyltransferase-like proteins DC4. The invention also provides the human, mouse and rat DC4 and rat and mouse DC4L associated with the cardiovascular diseases, dermatological diseases, metabolic diseases, muscle-skeleton disorders, cancer, inflammation, urological diseases, neurological diseases and hematological diseases. The invention also provides assays for the identification of compounds useful for the modulation of cardiovascular diseases, dermatological diseases, metabolic diseases, muscle-skeleton disorders, cancer, inflammation, urological diseases, neurological diseases and hematological diseases for treating of cardiovascular diseases, dermatological diseases, metabolic diseases, muscle-skeleton disorders, cancer, inflammation, urological diseases, neurological diseases and hematological diseases associated with expression of the DC4. The invention also features compounds which bind to and/or activate or inhibit the activity of DC4 as well as pharmaceutical compositions comprising such compounds.
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Inventors:
GOLZ STEFAN (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
Application Number:
PCT/EP2005/000631
Publication Date:
October 27, 2005
Filing Date:
January 22, 2005
Export Citation:
Assignee:
BAYER HEALTHCARE AG (DE)
GOLZ STEFAN (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
GOLZ STEFAN (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
International Classes:
C12N9/10; A61K38/00; (IPC1-7): C12N9/10; A61K38/17; C07K16/18; C12N5/10; C12N15/11; G01N33/50
Domestic Patent References:
| WO2002068595A2 | 2002-09-06 | |||
| WO2003053363A2 | 2003-07-03 | |||
| WO2004042014A2 | 2004-05-21 |
Other References:
DATABASE EMBL [online] 16 May 2001 (2001-05-16), "602633307F1 NCI_CGAP_Skn3 Homo sapiens cDNA clone IMAGE:4778665 5', mRNA sequence.", XP002339952, retrieved from EBI accession no. EM_PRO:BG743236 Database accession no. BG743236
DATABASE EMBL [online] 2 May 2001 (2001-05-02), "602620181F1 NCI_CGAP_Skn3 Homo sapiens cDNA clone IMAGE:4745396 5', mRNA sequence.", XP002339953, retrieved from EBI accession no. EM_PRO:BG674003 Database accession no. BG674003
CASES S ET AL: "Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 276, no. 42, 19 October 2001 (2001-10-19), pages 38870 - 38876, XP002199715, ISSN: 0021-9258
CHENG JEFFREY B ET AL: "Mammalian wax biosynthesis - II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 36, 3 September 2004 (2004-09-03), pages 37798 - 37807, XP002339073, ISSN: 0021-9258
DATABASE EMBL [online] 2 May 2001 (2001-05-02), "602620181F1 NCI_CGAP_Skn3 Homo sapiens cDNA clone IMAGE:4745396 5', mRNA sequence.", XP002339953, retrieved from EBI accession no. EM_PRO:BG674003 Database accession no. BG674003
CASES S ET AL: "Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 276, no. 42, 19 October 2001 (2001-10-19), pages 38870 - 38876, XP002199715, ISSN: 0021-9258
CHENG JEFFREY B ET AL: "Mammalian wax biosynthesis - II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 36, 3 September 2004 (2004-09-03), pages 37798 - 37807, XP002339073, ISSN: 0021-9258
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