Title:
NEW ANTIBACTERIAL PRODUCTS
Document Type and Number:
WIPO Patent Application WO/2016/034894
Kind Code:
A3
Abstract:
The invention provides a combination of an antibacterial agent (in particular vancomycin or moenomycin) and a delivery agent, in which the delivery agent is bonded, or capable of binding, to the antibacterial agent, and in which the delivery agent is capable of binding to one or more structures on a bacterial cell membrane. The invention further provides the use of such combinations in treating or preventing bacterial infections.
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Inventors:
SINGH ISHWAR (GB)
TAYLOR EDWARD (GB)
TAYLOR EDWARD (GB)
Application Number:
PCT/GB2015/052564
Publication Date:
April 21, 2016
Filing Date:
September 04, 2015
Export Citation:
Assignee:
SINGH ISHWAR (GB)
TAYLOR EDWARD (GB)
UNIV LINCOLN (GB)
TAYLOR EDWARD (GB)
UNIV LINCOLN (GB)
International Classes:
A61K38/14; A61K31/70; A61P31/04; C07C271/20; C07C277/08; C07H13/12; C07K9/00
Domestic Patent References:
| WO2002036612A1 | 2002-05-10 |
Other References:
CHRISTOPHER J. ARNUSCH ET AL: "Enhanced Membrane Pore Formation through High-Affinity Targeted Antimicrobial Peptides", PLOS ONE, vol. 7, no. 6, 29 June 2012 (2012-06-29), pages e39768, XP055140749, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0039768
SEOK KI CHOI ET AL: "Dendrimer-Based Multivalent Vancomycin Nanoplatform for Targeting the Drug-Resistant Bacterial Surface", ACS NANO, vol. 7, no. 1, 24 December 2012 (2012-12-24), US, pages 214 - 228, XP055230094, ISSN: 1936-0851, DOI: 10.1021/nn3038995
SHEPHERD J ET AL: "Hyperbranched poly(NIPAM) polymers modified with antibiotics for the reduction of bacterial burden in infected human tissue engineered skin", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 32, no. 1, 1 January 2011 (2011-01-01), pages 258 - 267, XP027493711, ISSN: 0142-9612, [retrieved on 20101113], DOI: 10.1016/J.BIOMATERIALS.2010.08.084
CHANDRASEKAR DURAIRAJ ET AL: "Nanosized Dendritic Polyguanidilyated Translocators for Enhanced Solubility, Permeability, and Delivery of Gatifloxacin", INVESTIGATIVE OPTHALMOLOGY & VISUAL SCIENCE, vol. 51, no. 11, 1 November 2010 (2010-11-01), US, pages 5804, XP055230049, ISSN: 1552-5783, DOI: 10.1167/iovs.10-5388
ALBERTO VENTURELLI ET AL: "Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy", JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, no. 23, 1 November 2007 (2007-11-01), US, pages 5644 - 5654, XP055230047, ISSN: 0022-2623, DOI: 10.1021/jm070643q
MALCOLM G. P. PAGE: "Siderophore conjugates", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1277, no. 1, 24 January 2013 (2013-01-24), pages 115 - 126, XP055149303, ISSN: 0077-8923, DOI: 10.1111/nyas.12024
TENGFEI ZHENG ET AL: "Siderophore-Mediated Cargo Delivery to the Cytoplasm of Escherichia coli and Pseudomonas aeruginosa : Syntheses of Monofunctionalized Enterobactin Scaffolds and Evaluation of Enterobactin-Cargo Conjugate Uptake", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134, no. 44, 7 November 2012 (2012-11-07), pages 18388 - 18400, XP055149011, ISSN: 0002-7863, DOI: 10.1021/ja3077268
BOHDAN OSTASH ET AL: "Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity", NATURAL PRODUCT REPORTS, vol. 27, no. 11, 1 January 2010 (2010-01-01), GB, pages 1594, XP055229738, ISSN: 0265-0568, DOI: 10.1039/c001461n
EL-ABADLA N ET AL: "Moenomycin A: The Role of the Methyl Group in the Moenuronamide Unit and a General Discussion of Structure-Activity Relationships", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 55, no. 3, 15 January 1999 (1999-01-15), pages 699 - 722, XP004151194, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(98)01063-1
SEOK KI CHOI ET AL: "Dendrimer-Based Multivalent Vancomycin Nanoplatform for Targeting the Drug-Resistant Bacterial Surface", ACS NANO, vol. 7, no. 1, 24 December 2012 (2012-12-24), US, pages 214 - 228, XP055230094, ISSN: 1936-0851, DOI: 10.1021/nn3038995
SHEPHERD J ET AL: "Hyperbranched poly(NIPAM) polymers modified with antibiotics for the reduction of bacterial burden in infected human tissue engineered skin", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 32, no. 1, 1 January 2011 (2011-01-01), pages 258 - 267, XP027493711, ISSN: 0142-9612, [retrieved on 20101113], DOI: 10.1016/J.BIOMATERIALS.2010.08.084
CHANDRASEKAR DURAIRAJ ET AL: "Nanosized Dendritic Polyguanidilyated Translocators for Enhanced Solubility, Permeability, and Delivery of Gatifloxacin", INVESTIGATIVE OPTHALMOLOGY & VISUAL SCIENCE, vol. 51, no. 11, 1 November 2010 (2010-11-01), US, pages 5804, XP055230049, ISSN: 1552-5783, DOI: 10.1167/iovs.10-5388
ALBERTO VENTURELLI ET AL: "Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy", JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, no. 23, 1 November 2007 (2007-11-01), US, pages 5644 - 5654, XP055230047, ISSN: 0022-2623, DOI: 10.1021/jm070643q
MALCOLM G. P. PAGE: "Siderophore conjugates", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1277, no. 1, 24 January 2013 (2013-01-24), pages 115 - 126, XP055149303, ISSN: 0077-8923, DOI: 10.1111/nyas.12024
TENGFEI ZHENG ET AL: "Siderophore-Mediated Cargo Delivery to the Cytoplasm of Escherichia coli and Pseudomonas aeruginosa : Syntheses of Monofunctionalized Enterobactin Scaffolds and Evaluation of Enterobactin-Cargo Conjugate Uptake", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134, no. 44, 7 November 2012 (2012-11-07), pages 18388 - 18400, XP055149011, ISSN: 0002-7863, DOI: 10.1021/ja3077268
BOHDAN OSTASH ET AL: "Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity", NATURAL PRODUCT REPORTS, vol. 27, no. 11, 1 January 2010 (2010-01-01), GB, pages 1594, XP055229738, ISSN: 0265-0568, DOI: 10.1039/c001461n
EL-ABADLA N ET AL: "Moenomycin A: The Role of the Methyl Group in the Moenuronamide Unit and a General Discussion of Structure-Activity Relationships", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 55, no. 3, 15 January 1999 (1999-01-15), pages 699 - 722, XP004151194, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(98)01063-1
Attorney, Agent or Firm:
MCNEENEY, Stephen Phillip (The Belgrave CentreTalbot Street, Nottingham NG1 5GG, GB)
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