Title:
NEW ANTIMICROBIAL AGENTS AGAINST STAPHYLOCOCCUS AUREUS
Document Type and Number:
WIPO Patent Application WO/2018/091707
Kind Code:
A9
Abstract:
The present invention relates to the field of antimicrobial agents active against Staphylococcus aureus bacteria. In particular, the present invention relates to polypeptides comprising the CHAP domain of LysK endolysin, the M23 endopeptidase domain of lysostaphin, the cell wall binding domain (CBD) of ALE-1, and a further peptide selected from the group consisting of an antimicrobial peptide, an amphipathic peptide, a cationic peptide, a hydrophobic peptide, a sushi peptide and a defensin. In addition, the present invention relates to nucleic acids encoding such polypeptides, vectors comprising such nucleic acids, and corresponding host cells, compositions and devices. Finally, the present invention relates to applications of the inventive polypeptides, in particular in the pharmaceutical field.
Inventors:
BIEBL MANFRED (DE)
GRIESSL MARTIN (DE)
NEUMANN KRISTIN (DE)
GRIESSL MARTIN (DE)
NEUMANN KRISTIN (DE)
Application Number:
PCT/EP2017/079769
Publication Date:
August 02, 2018
Filing Date:
November 20, 2017
Export Citation:
Assignee:
LYSANDO AG (LI)
International Classes:
A61K38/16; A61F2/07; A61F13/00; A61K38/06; A61K38/08; A61K38/10; A61K38/47; A61K38/48; A61L15/44; A61L27/00; A61M25/10; A61P31/04; C07K7/00; C07K7/06; C07K7/08; C07K14/47; C12N5/10; C12N9/36; C12N9/52; C12N15/62
Attorney, Agent or Firm:
RÜCKERL, Florian (DE)
Download PDF: