Title:
NEW APPLICATIONS OF LYSOZYME DIMER NEW APPLICATIONS OF LYSOZYME DIMER
Document Type and Number:
WIPO Patent Application WO1996021463
Kind Code:
A3
Abstract:
The present invention relates to pharmaceutical compositions containing a lysozyme dimer, preferably of high purity, i.e. with about 10 wt.% or less of unintended by-products, and new applications thereof. Such applications include topical, oral and parenteral administration of said compositions for non-specific immunostimulation as a measure of prevention and/or therapeutic treatment of human and animal diseases comprising cancer, hair growth disorders, fish diseases and bee diseases. The non-specific stimulation of the immune system is induced by a single or repeated application of the lysozyme dimer composition, preferably at concentrations of 5 to 500 mu g/kg body weight.
Inventors:
KICZKA WITOLD (US)
Application Number:
PCT/EP1996/000135
Publication Date:
September 19, 1996
Filing Date:
January 13, 1996
Export Citation:
Assignee:
NIKA HEALTH PRODUCTS LTD (LI)
KICZKA WITOLD (LI)
KICZKA WITOLD (LI)
International Classes:
A61K9/06; A61K38/46; A61K38/47; A61P13/02; A61P15/00; A61P31/12; A61P35/00; A61P37/00; A61K; C07K; C12N; (IPC1-7): A61K38/47
Domestic Patent References:
| WO1989011294A1 | 1989-11-30 | |||
| WO1994001127A1 | 1994-01-20 | |||
| WO1991010731A1 | 1991-07-25 |
Foreign References:
| EP0181634A2 | 1986-05-21 |
Other References:
BARTHOLEYNS ET AL: "IN VITRO AND IN VIVO ANTITUMOR EFFECT OF DIMERIZED RIBONUCLEASE A", EUROPEAN JOURNAL OF CANCER, vol. 15, no. 1, pages 85 - 91, XP002002104
BARTHOLEYNS ET AL: "CYSTOSTATIC EFFECT AND INHIBITION OF PROTEIN DEGRADATION BY DIMERIZED LYSOZYME:COMPARISON WITH THE EFFECT OF DIMERIZED RIBONUCLEASE AND REVERSIBILITY BY GALACTOSE", ARCHIVES INTERNATIONALES DE PHYSIOLOGIE ET DE BIOCHIMIE, vol. 87, pages 155 - 156, XP002002105
BARTHOLEYNS ET AL: "CYSTOSTATIC EFFECT AND INHIBITION OF PROTEIN DEGRADATION BY DIMERIZED LYSOZYME:COMPARISON WITH THE EFFECT OF DIMERIZED RIBONUCLEASE AND REVERSIBILITY BY GALACTOSE", ARCHIVES INTERNATIONALES DE PHYSIOLOGIE ET DE BIOCHIMIE, vol. 87, pages 155 - 156, XP002002105
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